PMID- 12653710
OWN - NLM
STAT- MEDLINE
DCOM- 20030519
LR  - 20190901
IS  - 0307-6938 (Print)
IS  - 0307-6938 (Linking)
VI  - 28
IP  - 2
DP  - 2003 Mar
TI  - The central role of FcepsilonRI in allergy.
PG  - 184-7
AB  - The high-affinity receptor for immunoglobulin E (IgE), FcepsilonRI, plays a 
      central role in the initiation and control of atopic allergic inflammation. On 
      mast cells and basophils, the function of the receptor is well known and 
      constitutes cellular degranulation and the release of various mediators. 
      FcepsilonRI on antigen-presenting cells (APCs), however, does not lead to 
      degranulation of preformed granula, but has different functions: signal 
      transduction pathways like the activation of NF-kappaB are initiated to induce 
      inflammatory cytokine gene expression. In addition, FcepsilonRI on APCs acts as 
      an allergen-focusing structure and can efficiently amplify allergen presentation 
      in an IgE-dependent manner. Recently, we and others have gained new insight into 
      the regulation and function of FcepsilonRI on APCs, which has shed new light on 
      the modulating effects of the immune system in atopic inflammation.
FAU - von Bubnoff, D
AU  - von Bubnoff D
AD  - Department of Dermatology, Friedrich-Wilhelms-University, Bonn, Germany. 
      d.bubnoff@uni-bonn.de
FAU - Novak, N
AU  - Novak N
FAU - Kraft, S
AU  - Kraft S
FAU - Bieber, T
AU  - Bieber T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Animals
MH  - *Antigen-Presenting Cells/immunology/metabolism
MH  - Asthma/immunology
MH  - Dermatitis, Atopic/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Receptors, IgE/*immunology
MH  - Rhinitis/immunology
MH  - T-Lymphocytes/immunology/metabolism
RF  - 22
EDAT- 2003/03/26 05:00
MHDA- 2003/05/20 05:00
CRDT- 2003/03/26 05:00
PHST- 2003/03/26 05:00 [pubmed]
PHST- 2003/05/20 05:00 [medline]
PHST- 2003/03/26 05:00 [entrez]
AID - 1209 [pii]
AID - 10.1046/j.1365-2230.2003.01209.x [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2003 Mar;28(2):184-7. doi: 10.1046/j.1365-2230.2003.01209.x.