PMID- 12653718
OWN - NLM
STAT- MEDLINE
DCOM- 20030519
LR  - 20220311
IS  - 0307-6938 (Print)
IS  - 0307-6938 (Linking)
VI  - 28
IP  - 2
DP  - 2003 Mar
TI  - Contact allergy: the local lymph node assay for the prediction of hazard and 
      risk.
PG  - 218-21
AB  - The prospective identification of potential contact allergens and their 
      subsequent safety assessment are pivotal in successful management of this risk to 
      human health. Although much can be learned from the chemical and physical 
      properties of a substance, the definitive information in respect of sensitizing 
      hazard/risk derives from an assessment of the integrated response of the immune 
      system. In recent years, the focus for such assessments has begun to switch from 
      the guinea pig to the mouse, notably to the local lymph node assay (LLNA). In 
      this paper, the current value of the LLNA for hazard identification is reviewed 
      and its regulatory status defined. Once a potential contact allergen has been 
      identified, however, the vital clue to accurate safety evaluation is the 
      assessment of the potency of the allergen. How this can be achieved using the 
      LLNA and employed in safety evaluation is discussed in detail, together with 
      practical suggestions for the deployment of such processes in regulatory 
      toxicology.
FAU - Basketter, D A
AU  - Basketter DA
AD  - Safety and Environmental Assurance Centre, Unilever Colworth, Sharnbrook, 
      Bedford, UK. David.Basketter@unilever.com
FAU - Smith Pease, C K
AU  - Smith Pease CK
FAU - Patlewicz, G Y
AU  - Patlewicz GY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*isolation & purification
MH  - Dermatitis, Allergic Contact/*diagnosis/immunology/prevention & control
MH  - Dose-Response Relationship, Immunologic
MH  - Humans
MH  - *Local Lymph Node Assay
MH  - Risk Assessment
EDAT- 2003/03/26 05:00
MHDA- 2003/05/20 05:00
CRDT- 2003/03/26 05:00
PHST- 2003/03/26 05:00 [pubmed]
PHST- 2003/05/20 05:00 [medline]
PHST- 2003/03/26 05:00 [entrez]
AID - 1247 [pii]
AID - 10.1046/j.1365-2230.2003.01247.x [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2003 Mar;28(2):218-21. doi: 10.1046/j.1365-2230.2003.01247.x.