PMID- 12654452
OWN - NLM
STAT- MEDLINE
DCOM- 20030506
LR  - 20220331
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 55
IP  - 5
DP  - 2003 Apr 1
TI  - Are multiple CT scans required for planning curative radiotherapy in lung tumors 
      of the lower lobe?
PG  - 1394-9
AB  - PURPOSE: Lung tumors located in the lower lobe are the most mobile. Multiple 
      computed tomographic (CT) scans, which had been performed for radiotherapy 
      planning, were analyzed to determine the minimal number of required scans. 
      METHODS AND MATERIALS: Six spiral CT scans (3 rapid and 3 slow) from 7 such 
      patients were coregistered. Reproducibility of target volumes was defined as the 
      ratio between the overlapping and encompassing volume (COM/SUM) from scans 
      derived using one technique. Volumetric and dosimetric analyses were performed. 
      RESULTS: Slow CT scans generated larger and more reproducible target volumes than 
      rapid planning scans, with a mean COM/SUM ratio of 71.9 +/- 8.7% and 58.0 +/- 
      12.7%, respectively. When only a single slow CT scan was used for planning, the 
      addition of a symmetrical 3D margin of 5 mm ensured 99% coverage of the "optimal" 
      target volume, which was derived from summation of target volumes from all six 
      scans. CONCLUSION: Planning target volumes (PTVs) derived from a single slow CT 
      scan plus a 5-mm margin covered the "optimal" PTVs generated from six scans. 
      Although these "slow PTVs" were larger, the increase in V(20) (the volume of lung 
      tissue receiving a dose > or = 20 Gy) was limited. This indicates that only two 
      CT scans, i.e., a full rapid scan of the entire thorax and a limited slow scan, 
      are necessary for treatment planning in peripheral lung cancers.
FAU - de Koste, John R van Sornsen
AU  - de Koste JR
AD  - Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The 
      Netherlands.
FAU - Lagerwaard, Frank J
AU  - Lagerwaard FJ
FAU - de Boer, Hans C J
AU  - de Boer HC
FAU - Nijssen-Visser, Margriet R J
AU  - Nijssen-Visser MR
FAU - Senan, Suresh
AU  - Senan S
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Artifacts
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/radiotherapy
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Lung/*diagnostic imaging
MH  - Lung Neoplasms/*diagnostic imaging/radiotherapy
MH  - Motion
MH  - Myocardial Contraction
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Reproducibility of Results
MH  - Respiration
MH  - *Tomography, X-Ray Computed
EDAT- 2003/03/26 05:00
MHDA- 2003/05/07 05:00
CRDT- 2003/03/26 05:00
PHST- 2003/03/26 05:00 [pubmed]
PHST- 2003/05/07 05:00 [medline]
PHST- 2003/03/26 05:00 [entrez]
AID - S0360301602046023 [pii]
AID - 10.1016/s0360-3016(02)04602-3 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1394-9. doi: 
      10.1016/s0360-3016(02)04602-3.