PMID- 12654774
OWN - NLM
STAT- MEDLINE
DCOM- 20030512
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 71
IP  - 4
DP  - 2003 Apr
TI  - Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa.
PG  - 1630-4
AB  - Interleukin-18 (IL-18) is a potent cytokine with many different proinflammatory 
      activities. To study the role of IL-18 in the pathogenesis of Pseudomonas 
      pneumonia, IL-18-deficient (IL-18(-/-)) and wild-type mice were intranasally 
      inoculated with Pseudomonas aeruginosa. IL-18 deficiency was associated with 
      reduced outgrowth of Pseudomonas in the lungs and diminished dissemination of the 
      infection. In addition, pulmonary inflammation (histopathology) and levels of 
      tumor necrosis factor alpha, IL-6, and macrophage inflammatory protein-2 in lungs 
      and plasma were lower in IL-18(-/-) mice. Consistent with results obtained for 
      IL-18(-/-) mice, treatment of wild-type mice with a neutralizing IL-18 binding 
      protein-immunoglobulin G Fc fusion construct also attenuated outgrowth of 
      Pseudomonas compared with that for mice treated with a control protein. These 
      results demonstrate that the presence of endogenous IL-18 activity facilitates 
      inflammatory responses in the lung during Pseudomonas pneumonia, concurrently 
      impairing bacterial clearance.
FAU - Schultz, Marc J
AU  - Schultz MJ
AD  - Laboratory of Experimental Internal Medicine, Department of Intensive Care 
      Medicine, C3-326, Academic Medical Center, University of Amsterdam, Meibergdreef 
      9, 1105 AZ Amsterdam, The Netherlands. m.j.schultz@amc.uva.nl
FAU - Knapp, Sylvia
AU  - Knapp S
FAU - Florquin, Sandrine
AU  - Florquin S
FAU - Pater, Jennie
AU  - Pater J
FAU - Takeda, Kiyoshi
AU  - Takeda K
FAU - Akira, Shizuo
AU  - Akira S
FAU - van der Poll, Tom
AU  - van der Poll T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - Cytokines/blood
MH  - Female
MH  - Interleukin-18/*physiology
MH  - Lung/*immunology/microbiology/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pneumonia, Bacterial/*immunology/microbiology/pathology
MH  - Pseudomonas Infections/*immunology/microbiology/pathology
MH  - Pseudomonas aeruginosa/*immunology
PMC - PMC152024
EDAT- 2003/03/26 05:00
MHDA- 2003/05/13 05:00
PMCR- 2003/04/01
CRDT- 2003/03/26 05:00
PHST- 2003/03/26 05:00 [pubmed]
PHST- 2003/05/13 05:00 [medline]
PHST- 2003/03/26 05:00 [entrez]
PHST- 2003/04/01 00:00 [pmc-release]
AID - 0886 [pii]
AID - 10.1128/IAI.71.4.1630-1634.2003 [doi]
PST - ppublish
SO  - Infect Immun. 2003 Apr;71(4):1630-4. doi: 10.1128/IAI.71.4.1630-1634.2003.