PMID- 12655581
OWN - NLM
STAT- MEDLINE
DCOM- 20030723
LR  - 20061115
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 17
IP  - 4
DP  - 2003 Apr
TI  - Dynamic MRI of breast hardness following radiation treatment.
PG  - 427-34
AB  - PURPOSE: To evaluate functional microvascular characteristics of breast 
      induration several years after radiation treatment using dynamic 
      contrast-enhanced magnetic resonance imaging (DCE-MRI) techniques. MATERIALS AND 
      METHODS: Fifteen women with moderate or marked breast induration after surgery 
      and radiotherapy for breast cancer (2-15 years) were examined. Images of the 
      irradiated breast (boost and nonboost sites) on short tau inversion recovery 
      (STIR) and DCE-MRI sequences were subjectively evaluated for edema and the 
      presence of enhancement and compared to the contralateral normal breast. 
      Quantitative enhancement parameters-percent enhancing pixels, transfer constant 
      (K(trans)), rate constant (k(ep)), leakage space (v(e)), and maximum contrast 
      medium accumulation (MCMA)-were also compared. RESULTS: No tumor recurrence was 
      seen. Fat necrosis was seen in 2/15 cases. Increased parenchymal edema at the 
      electron boost site was seen in 12/14 patients. Greater enhancement in the 
      irradiated breast was seen in 11/14 evaluable patients. Kinetic parameter 
      estimates including K(trans) were similar except for percent enhancing pixels, 
      which was greater in the irradiated breast at both boost and nonboost sites (P = 
      0.03 and 0.04, respectively). v(e) and MCMA estimates were greater in breasts 
      with marked induration compared to moderate grades (P = 0.002 and 0.01, 
      respectively). CONCLUSION: Parenchymal edema may be an important contributor to 
      palpable induration several years after breast radiotherapy. Increased fluid 
      content may be related to increased numbers of perfused microvessels and/or 
      impaired lymphatic drainage.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Padhani, Anwar R
AU  - Padhani AR
AD  - CRUK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and 
      the Royal Marsden Hospital, Downs Road, Sutton, UK. anwar@padhani.fsnt.co.uk
FAU - Yarnold, John
AU  - Yarnold J
FAU - Regan, Jane
AU  - Regan J
FAU - Husband, Janet E
AU  - Husband JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Breast/blood supply/pathology/*radiation effects
MH  - Breast Neoplasms/pathology/radiotherapy/surgery
MH  - Edema/etiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Radiotherapy/*adverse effects
MH  - Statistics, Nonparametric
EDAT- 2003/03/26 05:00
MHDA- 2003/07/24 05:00
CRDT- 2003/03/26 05:00
PHST- 2003/03/26 05:00 [pubmed]
PHST- 2003/07/24 05:00 [medline]
PHST- 2003/03/26 05:00 [entrez]
AID - 10.1002/jmri.10257 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2003 Apr;17(4):427-34. doi: 10.1002/jmri.10257.