PMID- 12656131
OWN - NLM
STAT- MEDLINE
DCOM- 20030410
LR  - 20221207
IS  - 1078-0998 (Print)
IS  - 1078-0998 (Linking)
VI  - 9
IP  - 1
DP  - 2003 Jan
TI  - A population- and family-based study of Canadian families reveals association of 
      HLA DRB1*0103 with colonic involvement in inflammatory bowel disease.
PG  - 1-9
AB  - The aim of this study was to identify major histocompatibility complex alleles 
      associated with the development and clinical features of inflammatory bowel 
      disease (IBD). Genotyping at the human leukocyte antigen (HLA) DRB1 and DQB1 loci 
      was performed on individuals from 118 Caucasian IBD sibling pair families and on 
      216 healthy controls. Both population- and family-based association tests were 
      used to analyze data obtained on the entire study population and on clinical 
      subgroups stratified by diagnosis, ethnicity, and disease distribution. HLA 
      DRB1*0103 was significantly associated with IBD (OR = 6.0, p = 0.0001) in a 
      case-control analysis of non-Jewish IBD-affected individuals. This association 
      was apparent among both Crohn's disease (OR = 5.23, p = 0.0007) and ulcerative 
      colitis (OR = 7.9, p = 0.0001) patients and was confirmed in the non-Jewish IBD 
      population by results of family-based association analysis using the transmission 
      disequilibrium test. HLA DQB1*0501 was also associated with IBD (OR = 1.64, p = 
      0.02) in the non-Jewish population. but statistically significant association of 
      this allele with disease was not detected for Crohn's disease and ulcerative 
      colitis separately. No significant associations were identified among the Jewish 
      patients. In the non-Jewish IBD families, IBD was as strongly associated with the 
      DRB1*0103 DQB1*0501 haplotype as with the DRB1*0103 allele alone. The carrier 
      frequency of the DRB1*0103 allele was found to be 10-fold higher in Crohn's 
      disease patients with pure colonic involvement than in healthy controls (38.5% 
      vs. 3.2%; p = 0.0002). These data demonstrate the association of the HLA 
      DRB1*0103 allele with both Crohn's disease and ulcerative colitis and with large 
      intestine-restricted disease in non-Jewish IBD patients and therefore identify 
      HLA DRB1*0103 as a potentially important contributor to disease susceptibility 
      and to expression of colonic involvement in IBD.
FAU - Silverberg, Mark S
AU  - Silverberg MS
AD  - Department of Medicine, University of Toronto, Toronto, Ontario, Canada. 
      msilverberg@mtsinai.on.ca
FAU - Mirea, Lucia
AU  - Mirea L
FAU - Bull, Shelley B
AU  - Bull SB
FAU - Murphy, Janet E
AU  - Murphy JE
FAU - Steinhart, A Hillary
AU  - Steinhart AH
FAU - Greenberg, Gordon R
AU  - Greenberg GR
FAU - McLeod, Robin S
AU  - McLeod RS
FAU - Cohen, Zane
AU  - Cohen Z
FAU - Wade, Judith A
AU  - Wade JA
FAU - Siminovitch, Katherine A
AU  - Siminovitch KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Canada
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Colitis, Ulcerative/complications/*genetics/*physiopathology
MH  - Colon/*physiopathology
MH  - Crohn Disease/complications/*genetics/*physiopathology
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Inflammatory Bowel Diseases/complications/*genetics/*physiopathology
MH  - Microsatellite Repeats/genetics
MH  - White People/*genetics
EDAT- 2003/03/27 05:00
MHDA- 2003/04/11 05:00
CRDT- 2003/03/27 05:00
PHST- 2003/03/27 05:00 [pubmed]
PHST- 2003/04/11 05:00 [medline]
PHST- 2003/03/27 05:00 [entrez]
AID - 10.1097/00054725-200301000-00001 [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2003 Jan;9(1):1-9. doi: 10.1097/00054725-200301000-00001.