PMID- 12657018
OWN - NLM
STAT- MEDLINE
DCOM- 20030723
LR  - 20190910
IS  - 0736-8046 (Print)
IS  - 0736-8046 (Linking)
VI  - 20
IP  - 2
DP  - 2003 Mar-Apr
TI  - Neonatal lupus erythematosus mimicking langerhans cell histiocytosis.
PG  - 164-6
AB  - Neonatal lupus erythematosus (NLE) is an autoimmune disease characterized 
      primarily by transient skin lesions and/or permanent congenital heart block. 
      Other clinical findings include self-limited cytopenias and liver disease. The 
      syndrome results from the passive transfer of maternal anti-SSA, anti-SSB, or 
      anti-U1RNP autoantibodies to the fetus across the placenta. The cutaneous 
      manifestations are generally analogous to those of subacute cutaneous lupus 
      erythematosus (SCLE) and consist of small, erythematous macules that progress to 
      annular plaques with delicate scaling. The skin lesions usually resolve within 
      the first 6 months of life as maternal autoantibodies are cleared from the 
      infant's circulation. We describe a patient with cutaneous NLE with hepatic and 
      hematologic manifestations. The clinical presentation was atypical, with 
      splenomegaly and petechiae at birth followed by a crusting, papulosquamous skin 
      eruption of the scalp and face mimicking Langerhans cell histiocytosis (LCH).
FAU - Scheker, Luis Emilio
AU  - Scheker LE
AD  - Division of Dermatology, Department of Medicine, University of Louisville School 
      of Medicine, Kentucky 40202, USA.
FAU - Kasteler, J Scott
AU  - Kasteler JS
FAU - Callen, Jeffrey P
AU  - Callen JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Antibodies, Antinuclear/analysis
MH  - Autoantibodies/analysis
MH  - Biopsy, Needle
MH  - Diagnosis, Differential
MH  - Facial Dermatoses/diagnosis
MH  - Female
MH  - Follow-Up Studies
MH  - Histiocytosis, Langerhans-Cell/*diagnosis
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant, Newborn
MH  - Lupus Erythematosus, Cutaneous/*diagnosis/*genetics
MH  - Pedigree
MH  - Risk Assessment
MH  - Severity of Illness Index
EDAT- 2003/03/27 05:00
MHDA- 2003/07/24 05:00
CRDT- 2003/03/27 05:00
PHST- 2003/03/27 05:00 [pubmed]
PHST- 2003/07/24 05:00 [medline]
PHST- 2003/03/27 05:00 [entrez]
AID - 20216 [pii]
AID - 10.1046/j.1525-1470.2003.20216.x [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2003 Mar-Apr;20(2):164-6. doi: 
      10.1046/j.1525-1470.2003.20216.x.