PMID- 12657202
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 2058-7384 (Electronic)
IS  - 0394-6320 (Linking)
VI  - 13
IP  - 3
DP  - 2000 Sep-Dec
TI  - Activation of murine bone-marrow derived macrophages in vitro with 
      Thymosin-alpha-1 to tumoricidal state: a comparative study on normal and 
      tumour-bearing hosts.
PG  - 129-140
AB  - The present investigation establishes the ability of Thymosin alpha l (T alpha l) 
      to activate murine bone-marrow derived macrophages (BMDMs) in vitro to 
      tumoricidal state with concomitant release of NO, TNFalpha and IL-1. The T alpha 
      l-induced cytotoxicity and the secretion of soluble lytic factors were both dose- 
      and time dependent. BMDMs cultured from the Dalton's Lymphoma bearing mice 
      (DL-BMDMs) exhibited reduced cytolytic activity towards DL-tumour target cells on 
      activation with T alpha l as compared to the BMDMs obtained from normal mice 
      (N-BMDMs). The DL-BMDMs displayed enhanced TNFalpha and IL-1 release as compared 
      to the N-BMDMs when treated with T alpha l. On the other hand, it is observed 
      that the production of NO and the expression of iNOS was higher in the N-BMDMs as 
      compared to the DL-BMDMs on treatment with T alpha l. Although T alpha l could 
      trigger the tumoricidal functions of BMDMs from normal and DL-tumor bearing 
      hosts, the progressive growth of DL-tumour in ascitic form leads to an alteration 
      in the antitumour response of macrophages. These observations further suggest 
      that a disregulation in the production of inflammatory cytokines like TNF-alpha, 
      IL-1 and the inhibition of NO production in response to DL growth may mutually 
      contribute in explaining the tumour-induced immunosuppression as observed in the 
      DL-bearing mice.
FAU - Paul, S
AU  - Paul S
AD  - School of Biotechnology, Banaras Hindu University, Varanasi, India.
FAU - Sodhi, A
AU  - Sodhi A
FAU - Biswas, S K
AU  - Biswas SK
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
EDAT- 2003/03/27 05:00
MHDA- 2003/03/27 05:00
CRDT- 2003/03/27 05:00
PHST- 2003/03/27 05:00 [pubmed]
PHST- 2003/03/27 05:00 [medline]
PHST- 2003/03/27 05:00 [entrez]
AID - 3 [pii]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2000 Sep-Dec;13(3):129-140.