PMID- 12658058
OWN - NLM
STAT- MEDLINE
DCOM- 20031014
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 41
IP  - 4
DP  - 2003 Apr
TI  - Ramatroban, a thromboxane A2 receptor antagonist, prevents macrophage 
      accumulation and neointimal formation after balloon arterial injury in 
      cholesterol-fed rabbits.
PG  - 571-8
AB  - Macrophage infiltration appears to play an important role in restenosis after 
      arterial intervention. Monocyte chemoattractant protein-1 (MCP-1) is a major 
      chemotactic factor for macrophages. We have previously shown that ramatroban, a 
      thromboxane A(2) (TXA(2)) receptor antagonist, diminished the expression of MCP-1 
      in human vascular endothelial cells. The aim of this study was to evaluate 
      whether, after balloon angioplasty of atherosclerotic arteries, ramatroban would 
      reduce MCP-1 expression, macrophage accumulation, and neointimal formation. New 
      Zealand white rabbits were fed a cholesterol-rich diet for 4 weeks, and the 
      abdominal aorta of the rabbits were injured by a 2-French Fogarty catheter. They 
      were randomized to receive 1 or 5 mg/kg daily of ramatroban (n = 7 or n = 8) or 
      saline (n = 6). At 4 weeks after balloon angioplasty, the intimal hyperplasia and 
      the macrophage-positive area in the intima by the ramatroban treatment was 
      significantly reduced. Monocyte chemoattractant protein-1 gene expression in 
      injured aortas of the ramatroban-treated group was significantly less evident 
      than in the vehicle-treated group. Thromboxane A(2) receptor blockade by 
      ramatroban for 4 weeks after balloon angioplasty in the atherosclerotic rabbits 
      prevented macrophage infiltration through MCP-1 downregulation and neointimal 
      formation.
FAU - Ishizuka, Toshiaki
AU  - Ishizuka T
AD  - Department of Medical Engineering, National Defense Medical College, Tokorozawa, 
      Saitama, Japan. TIR2@aol.com
FAU - Matsumura, Kouji
AU  - Matsumura K
FAU - Matsui, Takemi
AU  - Matsui T
FAU - Takase, Bonpei
AU  - Takase B
FAU - Kurita, Akira
AU  - Kurita A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Carbazoles)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, Thromboxane)
RN  - 0 (Sulfonamides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - P1ALI72U6C (ramatroban)
SB  - IM
MH  - Angioplasty, Balloon/*adverse effects/methods
MH  - Animals
MH  - Aorta, Abdominal/drug effects/metabolism/pathology
MH  - Carbazoles/*pharmacology
MH  - Chemokine CCL2/biosynthesis/genetics
MH  - Cholesterol/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/drug effects/physiology
MH  - Macrophages/*drug effects/pathology
MH  - Male
MH  - Rabbits
MH  - Receptors, Thromboxane/antagonists & inhibitors/physiology
MH  - Sulfonamides/*pharmacology
MH  - Tunica Intima/*drug effects/metabolism/pathology
EDAT- 2003/03/27 05:00
MHDA- 2003/10/15 05:00
CRDT- 2003/03/27 05:00
PHST- 2003/03/27 05:00 [pubmed]
PHST- 2003/10/15 05:00 [medline]
PHST- 2003/03/27 05:00 [entrez]
AID - 10.1097/00005344-200304000-00009 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 2003 Apr;41(4):571-8. doi: 
      10.1097/00005344-200304000-00009.