PMID- 12659352
OWN - NLM
STAT- MEDLINE
DCOM- 20030410
LR  - 20051116
IS  - 0038-4348 (Print)
IS  - 0038-4348 (Linking)
VI  - 96
IP  - 3
DP  - 2003 Mar
TI  - Is human herpesvirus 6 linked to kikuchi-fujimoto disease? The importance of 
      consistent molecular and serologic analysis.
PG  - 226-33
AB  - BACKGROUND: Kikuchi-Fujimoto disease, also called histiocytic necrotizing 
      lymphadenitis, is a self-limiting lymphadenopathy of unknown cause. The patient 
      often presents with fever, malaise, and lymphadenopathy primarily involving the 
      cervical lymph nodes. Laboratory findings are nonspecific, and the diagnosis is 
      established by identifying characteristic pathologic features from lymph node 
      biopsy. The etiologic agent has been proposed to be of viral origin; 
      specifically, human herpesvirus 6 (HHV-6) has been implicated. METHODS: The 
      clinical, histologic, serologic, and molecular data from 471 cases of 
      Kikuchi-Fujimoto disease reported between 1982 and 2001 and their relationship to 
      HHV-6 were reviewed. RESULTS: Thirty-two of the 471 patients in this review were 
      tested for HHV-6 serology; all 32 had elevated titers for HHV-6. One hundred 
      twelve patients with lymphadenopathies, including histiocytic necrotizing 
      lymphadenitis, tested positive for HHV-6 by polymerase chain reaction. In situ 
      hybridization results were positive in 41 cases. CONCLUSION: This review 
      illustrates the necessity for consistent molecular and serologic analysis.
FAU - Dominguez, Delfina C
AU  - Dominguez DC
AD  - Clinical Laboratory Science Program, University of Texas at El Paso, and U.S. 
      Oncology, El Paso, TX 79902, USA. delfina@utep.edu
FAU - Torres, M Lorraine
AU  - Torres ML
FAU - Antony, Suresh
AU  - Antony S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - South Med J
JT  - Southern medical journal
JID - 0404522
SB  - IM
MH  - Adult
MH  - Female
MH  - *Genetic Techniques
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Histiocytic Necrotizing Lymphadenitis/pathology/*virology
MH  - Humans
MH  - Lymphadenitis/pathology/virology
MH  - Middle Aged
MH  - *Serologic Tests
RF  - 60
EDAT- 2003/03/28 05:00
MHDA- 2003/04/11 05:00
CRDT- 2003/03/28 05:00
PHST- 2003/03/28 05:00 [pubmed]
PHST- 2003/04/11 05:00 [medline]
PHST- 2003/03/28 05:00 [entrez]
AID - 10.1097/01.SMJ.0000054420.01333.B0 [doi]
PST - ppublish
SO  - South Med J. 2003 Mar;96(3):226-33. doi: 10.1097/01.SMJ.0000054420.01333.B0.