PMID- 12659969
OWN - NLM
STAT- MEDLINE
DCOM- 20030522
LR  - 20191210
IS  - 0001-706X (Print)
IS  - 0001-706X (Linking)
VI  - 85
IP  - 3
DP  - 2003 Mar
TI  - Validation of ultrasonography for hepatic schistosomiasis using a porcine 
      Schistosoma japonicum model.
PG  - 315-23
AB  - Ultrasonography is increasingly used to record hepatosplenic involvement in 
      schistosomiasis. However, questions remain unsolved regarding diagnostic accuracy 
      in mild hepatic disease and under influence of confounders like co-infections. We 
      report on a study to evaluate the suitability of a pig model of schistosomiasis 
      japonica to investigate such problems. Nine pigs (12 weeks of age) were infected 
      with 1000 Schistosoma japonicum cercariae. Together with 10 uninfected controls, 
      they underwent B-mode and Doppler ultrasonography 12 weeks after infection, 
      followed by parasitological and gross pathological examination and quantification 
      of hepatic collagen. At this time, all infected pigs had patent infection, 
      hepatic displacement of ova and various grades of portal and septal liver 
      fibrosis. Sonographically, echogenic portal thickening (ePT), increased hepatic 
      echogenicity (EG), increased hepatic dimensions and dilatation of the portal vein 
      were found to correlate with other parameters of morbidity. Algorithms from human 
      medicine were appropriate to grade ePT in the pig model. It is concluded that the 
      porcine model of schistosomiasis japonica can be instrumental in approaching 
      problems which for any reasons cannot be studied in human beings.
FAU - Kardorff, Rudiger
AU  - Kardorff R
AD  - Department of Pediatrics, Marien-Hospital, Pastor-Janssen-Strasse 8-38, D-46483, 
      Wesel, Germany. ruediger.kardorff@marien-hospital-wesel.de
FAU - Eriksen, Lis
AU  - Eriksen L
FAU - Nielsen, Dorte Hald
AU  - Nielsen DH
FAU - Johansen, Maria Vang
AU  - Johansen MV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Blood Flow Velocity
MH  - Collagen/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Liver Diseases, Parasitic/*diagnostic imaging/parasitology
MH  - Male
MH  - Organ Size
MH  - Parasite Egg Count
MH  - Portal Vein/diagnostic imaging/pathology
MH  - Schistosoma japonicum/*growth & development
MH  - Schistosomiasis japonica/*diagnostic imaging/parasitology
MH  - Specific Pathogen-Free Organisms
MH  - Spleen/diagnostic imaging/parasitology/pathology
MH  - Swine
MH  - Ultrasonography, Doppler
EDAT- 2003/03/28 05:00
MHDA- 2003/05/23 05:00
CRDT- 2003/03/28 05:00
PHST- 2003/03/28 05:00 [pubmed]
PHST- 2003/05/23 05:00 [medline]
PHST- 2003/03/28 05:00 [entrez]
AID - S0001706X02002681 [pii]
AID - 10.1016/s0001-706x(02)00268-1 [doi]
PST - ppublish
SO  - Acta Trop. 2003 Mar;85(3):315-23. doi: 10.1016/s0001-706x(02)00268-1.