PMID- 12660035
OWN - NLM
STAT- MEDLINE
DCOM- 20030507
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 142
IP  - 1
DP  - 2003 Apr 1
TI  - Unusual karyotype aberrations involving 2p12, 3q27, 18q21, 8q24, and 14q32 in a 
      patient with non-Hodgkin lymphoma/acute lymphoblastic leukemia.
PG  - 60-4
AB  - The t(2;18)(p12;q21), known as a rare variant of the t(14;18)(q32;q21), together 
      with t(3;14)(q27;q32), t(8;15)(q24;q22) and two other unusual translocations 
      involving chromosomes 6, 9, 12, and 13, were demonstrated in the bone marrow 
      cells of a 70-year-old male with suspected non-Hodgkin lymphoma/acute 
      lymphoblastic leukemia. The complex chromosomal aberrations were identified by 
      chromosome banding analysis and by fluorescence in situ hybridization (FISH) with 
      whole chromosome painting probes, centromere-specific alpha-satellite probes, and 
      probes specific for genomic sequences of some likely to be involved candidate 
      genes. Several but not all of the chromosomal aberrations could be proved by 
      multicolor FISH. Possible mechanisms leading to this unusual karyotype commonly 
      associated with different histologic lymphoma subtypes and their prognostic 
      implications are discussed.
FAU - Okhowat, Roberta
AU  - Okhowat R
AD  - Institut fur Medizinische Biologie der Universitat Wien, 1090 Vienna, Austria.
FAU - Dorner, Stefan
AU  - Dorner S
FAU - Hinterberger, Wolfgang
AU  - Hinterberger W
FAU - Fonatsch, Christa
AU  - Fonatsch C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
SB  - IM
MH  - Aged
MH  - Centromere/genetics
MH  - Chromosome Aberrations
MH  - *Chromosomes, Human
MH  - DNA Probes/genetics
MH  - Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 2003/03/28 05:00
MHDA- 2003/05/08 05:00
CRDT- 2003/03/28 05:00
PHST- 2003/03/28 05:00 [pubmed]
PHST- 2003/05/08 05:00 [medline]
PHST- 2003/03/28 05:00 [entrez]
AID - S0165460802008014 [pii]
AID - 10.1016/s0165-4608(02)00801-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Apr 1;142(1):60-4. doi: 
      10.1016/s0165-4608(02)00801-4.