PMID- 12660216
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20190605
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 73
IP  - 4
DP  - 2003 Apr
TI  - Endogenous versus exogenous glucocorticoid responses to experimental bacterial 
      sepsis.
PG  - 417-27
AB  - Although lack of adrenals dramatically reduces resistance against sepsis 
      generally, the value of glucocorticoid levels above those normally produced by 
      stress remains controversial. An early and long-held concept is that 
      glucocorticoid protection against lipopolysaccharides in animal models is 
      important. Supporting this concept, C3H/HeJ mice, lacking Toll-like receptor-4 
      (TLR-4), and consequently, endotoxin hyporesponsive, have recently been shown to 
      be resistant to glucocorticoid protection against live Escherichia coli. 
      Effective antibiotic intervention, as an additional parameter and with 
      concomitant administration of glucocorticoid, not only allows for expected 
      antibiotic protection but also for glucocorticoid protection against E. coli or 
      Staphylococcus aureus of mice sensitized to tumor necrosis factor alpha, 
      regardless of the status of the TLR-4 receptor. TLRs, including but not limited 
      to TLR-2, may be involved in glucocorticoid protective efficacy against 
      Gram-positive and Gram-negative sepsis. Overlapping and possibly 
      endotoxin-independent signaling may become important considerations.
FAU - Silverstein, Richard
AU  - Silverstein R
AD  - Department of Biochemistry, University of Kansas School of Medicine, Kansas City, 
      USA. rsilvers@kumc.edu
FAU - Johnson, Donald C
AU  - Johnson DC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Drosophila Proteins)
RN  - 0 (Glucocorticoids)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Bacteremia/*prevention & control
MH  - *Drosophila Proteins
MH  - Escherichia coli Infections/*prevention & control
MH  - Glucocorticoids/*pharmacology/*physiology
MH  - Membrane Glycoproteins/physiology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Receptors, Cell Surface/physiology
MH  - Staphylococcal Infections/*prevention & control
MH  - Toll-Like Receptor 2
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
RF  - 107
EDAT- 2003/03/28 05:00
MHDA- 2003/05/16 05:00
CRDT- 2003/03/28 05:00
PHST- 2003/03/28 05:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2003/03/28 05:00 [entrez]
AID - 10.1189/jlb.0702379 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2003 Apr;73(4):417-27. doi: 10.1189/jlb.0702379.