PMID- 12661059
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20131121
IS  - 0022-3549 (Print)
IS  - 0022-3549 (Linking)
VI  - 92
IP  - 4
DP  - 2003 Apr
TI  - Microemulsions for dermal drug delivery studied by dynamic light scattering: 
      effect of interparticle interactions in oil-in-water microemulsions.
PG  - 730-8
AB  - Dynamic light scattering (DLS) was used to study the droplet size and the droplet 
      interaction of o/w microemulsions (MEs) consisting of oils, a blend of a high and 
      a low hydrophilic-lipophilic balance (HLB) surfactant, and a hydrophilic phase 
      (propylene glycol/water). Like many MEs, these systems could not be diluted to 
      infinite dilution without phase separation. Consequently, to allow a meaningful 
      calculation of droplet diameter from data obtained from DLS, it is necessary to 
      correct scattering measurements in high concentration regions for the nonideality 
      arising from interparticle interaction. Scattering data were corrected for 
      interparticle interaction using a suitable interaction model proposed for our 
      systems. From the total interparticle interaction energy, coagulation time was 
      calculated. The ratio between rapid and slow coagulation was of the order of 
      10(100), which is consistent with the observed stability of the MEs studied.
CI  - Copyright 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association J 
      Pharm Sci 92:730-738, 2003
FAU - Shukla, Anuj
AU  - Shukla A
AD  - Department of Physics, Optics Group, Martin-Luther-University Halle-Wittenberg, 
      06099 Halle/Saale, Germany.
FAU - Janich, Martin
AU  - Janich M
FAU - Jahn, Konstanze
AU  - Jahn K
FAU - Neubert, Reinhard H H
AU  - Neubert RH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Emulsions)
RN  - 0 (Lactates)
RN  - 0 (Oils)
RN  - 0 (Palmitates)
RN  - 0 (Polysorbates)
RN  - 0 (Surface-Active Agents)
RN  - 059QF0KO0R (Water)
RN  - 106392-12-5 (Poloxamer)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 8CRQ2TH63M (isopropyl palmitate)
RN  - G5SU0BFK7O (Eutanol G)
SB  - IM
MH  - Administration, Cutaneous
MH  - Algorithms
MH  - Chemistry, Pharmaceutical
MH  - Drug Stability
MH  - Emulsions/*chemistry
MH  - Lactates/chemistry
MH  - Light
MH  - Oils/*chemistry
MH  - Oleic Acid/chemistry
MH  - Palmitates/chemistry
MH  - Particle Size
MH  - Poloxamer/chemistry
MH  - Polysorbates/chemistry
MH  - Scattering, Radiation
MH  - Surface-Active Agents/*chemistry
MH  - Water/*chemistry
EDAT- 2003/03/28 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/03/28 05:00
PHST- 2003/03/28 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/03/28 05:00 [entrez]
AID - S0022-3549(16)31226-6 [pii]
AID - 10.1002/jps.10333 [doi]
PST - ppublish
SO  - J Pharm Sci. 2003 Apr;92(4):730-8. doi: 10.1002/jps.10333.