PMID- 12662150
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20191025
IS  - 1471-2598 (Print)
IS  - 1471-2598 (Linking)
VI  - 3
IP  - 2
DP  - 2003 Apr
TI  - Efficacy and safety of HLA-B7/beta-2 microglobulin plasmid DNA/lipid complex 
      (Allovectin-7) in patients with metastatic melanoma.
PG  - 377-84
AB  - Human leukocyte antigen (HLA)-B7/beta-2 microglobulin plasmid DNA/lipid complex, 
      otherwise known as Allovectin-7 (Vical, Inc., San Diego, CA, USA), has been 
      developed as a non-viral gene delivery product. After multiple laboratory and 
      human trials, it appears that the concept of gene transfer has established itself 
      as a clinical reality. While the manifestations of the gene transfer have not 
      been as dramatic as one might have hoped, HLA-B7/beta-2 microglobulin plasmid 
      DNA/lipid complex appears to be a promising agent with an extremely safe toxicity 
      profile. Ongoing trials are further investigating potential clinical uses of 
      Allovectin-7.
FAU - Bergen, Michael
AU  - Bergen M
AD  - University of Colorado Cancer Center, Anschutz Cancer Pavilion, PO Box 6510, Mail 
      Stop F 703, Aurora, Colorado 80010, USA. Michael.Bergen@uchsc.edu
FAU - Chen, Robert
AU  - Chen R
FAU - Gonzalez, Rene
AU  - Gonzalez R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (Allovectin-7)
RN  - 0 (DNA, Recombinant)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (Lipids)
RN  - 0 (Liposomes)
RN  - 0 (beta 2-Microglobulin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Clinical Trials, Phase I as Topic
MH  - Clinical Trials, Phase II as Topic
MH  - Clinical Trials, Phase III as Topic
MH  - DNA/adverse effects/pharmacokinetics/*therapeutic use
MH  - DNA, Recombinant
MH  - HLA-B7 Antigen/*genetics
MH  - Humans
MH  - Lipids/adverse effects/pharmacokinetics/*therapeutic use
MH  - Liposomes
MH  - Melanoma/*therapy
MH  - Neoplasm Metastasis
MH  - Plasmids/*genetics
MH  - beta 2-Microglobulin/*genetics
RF  - 56
EDAT- 2003/03/29 05:00
MHDA- 2004/07/14 05:00
CRDT- 2003/03/29 05:00
PHST- 2003/03/29 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2003/03/29 05:00 [entrez]
AID - 10.1517/14712598.3.2.377 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2003 Apr;3(2):377-84. doi: 10.1517/14712598.3.2.377.