PMID- 12663229
OWN - NLM
STAT- MEDLINE
DCOM- 20031216
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 38
IP  - 4
DP  - 2003 Apr
TI  - Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis.
PG  - 401-6
AB  - BACKGROUND/AIMS: Primary biliary cirrhosis (PBC) is an autoimmune cholestatic 
      liver disease of unknown etiology with a highly variable progression rate and 
      prevalence among different geographical areas. Data concerning human leukocyte 
      antigen (HLA) polymorphisms in PBC come from a limited number of geographical 
      areas, from which the association with the HLA-DRB1*08 allele has been 
      consistently reported. METHODS: To investigate whether HLA polymorphisms 
      contribute toward disease susceptibility, we compared 186 well-defined Italian 
      PBC patients with 558 healthy subjects matched by age, gender and geographical 
      area (Northern, Central and Southern Italy). Patients and controls were HLA typed 
      at low resolution by PCR-sequence specific oligonucleotides for the loci A and B; 
      HLA-DRB1 alleles were typed by reverse line blot assay of PCR-amplified DNA. 
      RESULTS: HLA-DRB1*11 was associated with a markedly reduced risk of developing 
      PBC (OR: 0.3; 95% CI: 0.2-0.5). No association was found with HLA-DRB1*08. The 
      B*15 (2.5; 1.3-4.6), B*41 (12.0; 2.7-72.1), B*55 (2.9; 1.1-7.5) and B*58 alleles 
      (6.8; 1.1-46.3) were more frequent in PBC. The frequency of HLA polymorphisms was 
      similar in PBC patients with progressive or non-progressive disease, and in those 
      with or without anti-mitochondrial antibodies. CONCLUSIONS: Our data on a large 
      series of Italian patients suggest that PBC may have a peculiar genetic 
      background in the Mediterranean area.
FAU - Invernizzi, Pietro
AU  - Invernizzi P
AD  - Department of Medicine, San Paolo Hospital Medical School, University of Milan, 
      Via di Rudini; 8, 20142 Milan, Italy. pietro.invernizzi@unimi.it
FAU - Battezzati, Pier Maria
AU  - Battezzati PM
FAU - Crosignani, Andrea
AU  - Crosignani A
FAU - Perego, Francesca
AU  - Perego F
FAU - Poli, Francesca
AU  - Poli F
FAU - Morabito, Alberto
AU  - Morabito A
FAU - De Arias, Alejandro Espadas
AU  - De Arias AE
FAU - Scalamogna, Mario
AU  - Scalamogna M
FAU - Zuin, Massimo
AU  - Zuin M
FAU - Podda, Mauro
AU  - Podda M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
EDAT- 2003/03/29 05:00
MHDA- 2003/12/17 05:00
CRDT- 2003/03/29 05:00
PHST- 2003/03/29 05:00 [pubmed]
PHST- 2003/12/17 05:00 [medline]
PHST- 2003/03/29 05:00 [entrez]
AID - S0168827802004403 [pii]
AID - 10.1016/s0168-8278(02)00440-3 [doi]
PST - ppublish
SO  - J Hepatol. 2003 Apr;38(4):401-6. doi: 10.1016/s0168-8278(02)00440-3.