PMID- 12663806
OWN - NLM
STAT- MEDLINE
DCOM- 20030505
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 77
IP  - 8
DP  - 2003 Apr
TI  - Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q 
      complex associates with human CD46.
PG  - 4992-9
AB  - Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry 
      into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We 
      show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of 
      gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating 
      that the complex is a viral ligand for CD46.
FAU - Mori, Yasuko
AU  - Mori Y
AD  - Department of Microbiology, Osaka University Medical School, Suita, Osaka 
      565-0871, USA. ymori@micro.med.osaka-u.ac.jp
FAU - Yang, Xuwei
AU  - Yang X
FAU - Akkapaiboon, Pilailuk
AU  - Akkapaiboon P
FAU - Okuno, Toshiomi
AU  - Okuno T
FAU - Yamanishi, Koichi
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antigens, CD)
RN  - 0 (CD46 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Membrane Cofactor Protein)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Virus)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Viral Envelope Proteins)
RN  - 142985-75-9 (glycoprotein H, herpesvirus 6)
SB  - IM
MH  - Antigens, CD/genetics/*metabolism
MH  - Baculoviridae/genetics
MH  - Cell Fusion
MH  - Cell Line
MH  - Herpesvirus 6, Human/classification/genetics/*pathogenicity
MH  - Humans
MH  - Ligands
MH  - Membrane Cofactor Protein
MH  - Membrane Fusion
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Receptors, Virus/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Viral Envelope Proteins/*metabolism
PMC - PMC152135
EDAT- 2003/03/29 05:00
MHDA- 2003/05/06 05:00
PMCR- 2003/04/01
CRDT- 2003/03/29 05:00
PHST- 2003/03/29 05:00 [pubmed]
PHST- 2003/05/06 05:00 [medline]
PHST- 2003/03/29 05:00 [entrez]
PHST- 2003/04/01 00:00 [pmc-release]
AID - 2084 [pii]
AID - 10.1128/jvi.77.8.4992-4999.2003 [doi]
PST - ppublish
SO  - J Virol. 2003 Apr;77(8):4992-9. doi: 10.1128/jvi.77.8.4992-4999.2003.