PMID- 12663985
OWN - NLM
STAT- MEDLINE
DCOM- 20030509
LR  - 20220330
IS  - 0741-5214 (Print)
IS  - 0741-5214 (Linking)
VI  - 37
IP  - 4
DP  - 2003 Apr
TI  - Superficial thrombophlebitis and risk for recurrent venous thromboembolism.
PG  - 834-8
AB  - OBJECTIVE: Superficial thrombophlebitis (ST) is a frequent and potentially 
      serious disease if complicated with venous thromboembolism (VTE). Data on risk 
      factors and incidence rates for ST are scarce. It is also unknown whether ST is a 
      risk factor for recurrence of VTE. METHODS: After discontinuation of secondary 
      thromboprophylaxis for a first spontaneous VTE, we prospectively observed 615 
      patients on average for 30 +/- 26 months. Patients with natural coagulation 
      inhibitor deficiency, lupus anticoagulant, or cancer, who were pregnant, or were 
      receiving long-term antithrombotic therapy were excluded. The study outcomes were 
      occurrence of symptomatic ST or objectively documented recurrent symptomatic VTE. 
      RESULTS: ST developed in 45 patients (7.3%) with a first VTE. High factor VIII 
      concentration emerged as an independent risk factor for ST (relative risk [RR], 
      2.0; 95% confidence interval [CI], 1.0-5.2), compared with lower levels after 
      adjustment for age and sex; factor V Leiden and prothrombin G20210A 
      concentration; hyperhomocysteinemia; high body mass index; and duration of oral 
      anticoagulation therapy. VTE recurred in 12 (27%) of 45 patients with ST and in 
      67 (12%) of 570 patients without ST. In patients with VTE, subsequent ST emerged 
      as an independent risk factor for recurrent VTE. Patients with ST had twofold 
      higher RR (2.1; 95% CI, 1.0-4.2) for recurrence than did patients without ST 
      after adjustment for putative confounding variables. CONCLUSION: Patients with a 
      first spontaneous VTE and subsequent ST are at increased risk for recurrent VTE. 
      High factor VIII concentration is an independent risk factor for ST.
FAU - Schonauer, Verena
AU  - Schonauer V
AD  - Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna 
      University Hospital, Vienna, Austria.
FAU - Kyrle, Paul A
AU  - Kyrle PA
FAU - Weltermann, Ansgar
AU  - Weltermann A
FAU - Minar, Erich
AU  - Minar E
FAU - Bialonczyk, Christine
AU  - Bialonczyk C
FAU - Hirschl, Mirko
AU  - Hirschl M
FAU - Quehenberger, Peter
AU  - Quehenberger P
FAU - Schneider, Barbara
AU  - Schneider B
FAU - Partsch, Hugo
AU  - Partsch H
FAU - Eichinger, Sabine
AU  - Eichinger S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
RN  - 9001-27-8 (Factor VIII)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Factor VIII/analysis
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Observation
MH  - Prospective Studies
MH  - Pulmonary Embolism/*etiology
MH  - Recurrence
MH  - Risk Factors
MH  - Thromboembolism/*complications/epidemiology
MH  - Thrombophlebitis/blood/*complications/epidemiology
EDAT- 2003/03/29 05:00
MHDA- 2003/05/13 05:00
CRDT- 2003/03/29 05:00
PHST- 2003/03/29 05:00 [pubmed]
PHST- 2003/05/13 05:00 [medline]
PHST- 2003/03/29 05:00 [entrez]
AID - S0741521402752981 [pii]
AID - 10.1067/mva.2003.157 [doi]
PST - ppublish
SO  - J Vasc Surg. 2003 Apr;37(4):834-8. doi: 10.1067/mva.2003.157.