PMID- 12665857
OWN - NLM
STAT- MEDLINE
DCOM- 20030529
LR  - 20071108
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 4
IP  - 5
DP  - 2003 May
TI  - Monoallelic expression of the murine gene encoding Toll-like receptor 4.
PG  - 464-70
AB  - Defects in the gene encoding Toll-like receptor 4 (Tlr4) result in impaired 
      responses to lipopolysaccharide (LPS), rendering mice sensitive to infections by 
      Gram-negative bacteria. C3H/HeJ mice have a codominant allele with a mutation in 
      Tlr4, which results in an intermediate response to LPS in F1 mice from crosses of 
      responder and C3H/HeJ mice. Here we show that this intermediate response to LPS 
      is due to monoallelic expression of Tlr4. Allele usage is maintained during 
      clonal expansion, a situation that resembles allelic exclusion. In contrast, Tlr4 
      is deleted on the recessive C57BL/10ScCr allele and all cells from F1 mice from 
      crosses of responder and C57BL/10ScCr mice express TLR4 protein. Thus, Tlr4 is an 
      autosomal gene whose expression is regulated similarly to that of genes on the X 
      chromosome.
FAU - Pereira, Joao Pedro
AU  - Pereira JP
AD  - Unite du Developpement des Lymphocytes, CNRS URA 1961, Institut Pasteur, 25 Rue 
      du Docteur Roux, 75015 Paris, France.
FAU - Girard, Robert
AU  - Girard R
FAU - Chaby, Richard
AU  - Chaby R
FAU - Cumano, Ana
AU  - Cumano A
FAU - Vieira, Paulo
AU  - Vieira P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030331
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Drosophila Proteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - B-Lymphocytes/cytology/drug effects/immunology
MH  - Base Sequence
MH  - Cell Differentiation
MH  - Crosses, Genetic
MH  - DNA/genetics
MH  - *Drosophila Proteins
MH  - Gene Expression Regulation, Developmental
MH  - Gram-Negative Bacterial Infections/genetics/immunology
MH  - Granulocytes/drug effects/immunology
MH  - Lipopolysaccharides/pharmacology
MH  - Lymphocyte Activation
MH  - Membrane Glycoproteins/*genetics
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Receptors, Cell Surface/*genetics
MH  - Species Specificity
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
EDAT- 2003/04/01 05:00
MHDA- 2003/05/30 05:00
CRDT- 2003/04/01 05:00
PHST- 2002/11/27 00:00 [received]
PHST- 2003/02/28 00:00 [accepted]
PHST- 2003/04/01 05:00 [pubmed]
PHST- 2003/05/30 05:00 [medline]
PHST- 2003/04/01 05:00 [entrez]
AID - ni917 [pii]
AID - 10.1038/ni917 [doi]
PST - ppublish
SO  - Nat Immunol. 2003 May;4(5):464-70. doi: 10.1038/ni917. Epub 2003 Mar 31.