PMID- 12667151
OWN - NLM
STAT- MEDLINE
DCOM- 20030612
LR  - 20191210
IS  - 1360-2276 (Print)
IS  - 1360-2276 (Linking)
VI  - 8
IP  - 4
DP  - 2003 Apr
TI  - Lot quality assurance sampling for screening communities hyperendemic for 
      Schistosoma mansoni.
PG  - 322-8
AB  - Lot quality assurance sampling (LQAS) was evaluated for rapid low cost 
      identification of communities where Schistosoma mansoni infection was 
      hyperendemic in southern Madagascar. In the study area, S. mansoni infection 
      shows very focused and heterogeneous distribution requiring multifariousness of 
      local surveys. One sampling plan was tested in the field with schoolchildren and 
      several others were simulated in the laboratory. Randomization and stool specimen 
      collection were performed by voluntary teachers under direct supervision of the 
      study staff and no significant problem occurred. As expected from Receiver 
      Operating Characteristic (ROC) curves, all sampling plans allowed correct 
      identification of hyperendemic communities and of most of the hypoendemic ones. 
      Frequent misclassifications occurred for communities with intermediate prevalence 
      and the cheapest plans had very low specificity. The study confirmed that LQAS 
      would be a valuable tool for large scale screening in a country with scarce 
      financial and staff resources. Involving teachers, appeared to be quite feasible 
      and should not lower the reliability of surveys. We recommend that the national 
      schistosomiasis control programme systematically uses LQAS for identification of 
      communities, provided that sample sizes are adapted to the specific 
      epidemiological patterns of S. mansoni infection in the main regions.
FAU - Rabarijaona, L P
AU  - Rabarijaona LP
AD  - Unite d'Epidemiologie, Institut Pasteur de Madagascar, Antananarivo, Madagascar. 
      leon@pasteur.mg
FAU - Boisier, P
AU  - Boisier P
FAU - Ravaoalimalala, V E
AU  - Ravaoalimalala VE
FAU - Jeanne, I
AU  - Jeanne I
FAU - Roux, J F
AU  - Roux JF
FAU - Jutand, M A
AU  - Jutand MA
FAU - Salamon, R
AU  - Salamon R
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Endemic Diseases
MH  - Female
MH  - Humans
MH  - Madagascar/epidemiology
MH  - Male
MH  - Mass Screening/*methods
MH  - Quality Assurance, Health Care/*methods
MH  - ROC Curve
MH  - Sampling Studies
MH  - Schistosomiasis/diagnosis/*epidemiology
MH  - Schools
MH  - Sensitivity and Specificity
MH  - Specimen Handling/methods
EDAT- 2003/04/02 05:00
MHDA- 2003/06/13 05:00
CRDT- 2003/04/02 05:00
PHST- 2003/04/02 05:00 [pubmed]
PHST- 2003/06/13 05:00 [medline]
PHST- 2003/04/02 05:00 [entrez]
AID - 1019 [pii]
AID - 10.1046/j.1365-3156.2003.01019.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2003 Apr;8(4):322-8. doi: 10.1046/j.1365-3156.2003.01019.x.