PMID- 12667294
OWN - NLM
STAT- MEDLINE
DCOM- 20031009
LR  - 20171116
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 11
IP  - 1
DP  - 2003 Feb
TI  - [Effect of activation of cellular immunity on p58+ cells expressing 
      killer-cell-inhibitory receptor cells].
PG  - 70-3
AB  - The purpose of this study was to evaluate the effects of cellular immunity 
      activation on P58(+) cells expressing killer cell inhibitory receptor (KIR) and 
      their regulatory function on cellular immunity, and provid theoretical data for 
      preventing graft-vers-host disease (GVHD) in stem cell transplantation therapy. 
      The mononuclear cells from human peripheral blood were incubated with IL-2, Con A 
      and Lipostin (LP) for 72 hours. The KIR expressing cells, P58.1(+) and P58.2(+) 
      cells, were analyzed by flow cytometry. The results showed that the percentages 
      of CD3(+), CD4(+), CD8(+), CD16(+)CD56(+), P58.1(+) and P58.2(+) cells were 
      greatly increased after treated with IL-2, Con A and LP, separately or in 
      combination, and the percentages of above cells in combined treatment groups were 
      higher than those of single stimulated groups, especially the percentage of cells 
      in the IL-2 + LP group was significantly higher than those in IL-2 and LP singly 
      treated groups. IN CONCLUSION: IL-2, Con A and LP possess the ability to induce 
      the expression of KIR and stimulate proliferation of P58.1(+) and P58.2(+) cells 
      while to activate the celluar immunity response, the expression of P58 gene may 
      be regulated by the activation of cellular immunity.
FAU - Pang, Xing-Hua
AU  - Pang XH
AD  - Department of Hematology, Zhujiang Hospital, The First Military Medical 
      University, Guangzhou 510282, China. xinghuapan@yahoo.com.cn
FAU - Pang, Rong-Qing
AU  - Pang RQ
FAU - Guo, Kun-Yuan
AU  - Guo KY
FAU - Song, Jiu-Gang
AU  - Song JG
FAU - Li, Jiang-Qi
AU  - Li JQ
FAU - Zhang, Yu-Jin
AU  - Zhang YJ
FAU - Yang, Xiao-Fen
AU  - Yang XF
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD56 Antigen)
RN  - 0 (CD8 Antigens)
RN  - 0 (Interleukin-2)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (Receptors, IgG)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL3)
RN  - 11028-71-0 (Concanavalin A)
SB  - IM
MH  - Adult
MH  - CD3 Complex/analysis
MH  - CD4 Antigens/analysis
MH  - CD56 Antigen/analysis
MH  - CD8 Antigens/analysis
MH  - Cell Count
MH  - Cell Division/drug effects
MH  - Concanavalin A/pharmacology
MH  - Flow Cytometry
MH  - Humans
MH  - Interleukin-2/pharmacology
MH  - Leukocytes, Mononuclear/cytology/drug effects/*immunology
MH  - Receptors, IgG/analysis
MH  - Receptors, Immunologic/*analysis
MH  - Receptors, KIR
MH  - Receptors, KIR2DL3
EDAT- 2003/04/02 05:00
MHDA- 2003/10/10 05:00
CRDT- 2003/04/02 05:00
PHST- 2003/04/02 05:00 [pubmed]
PHST- 2003/10/10 05:00 [medline]
PHST- 2003/04/02 05:00 [entrez]
AID - 1009-2137(2003)01-0070-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Feb;11(1):70-3.