PMID- 12668282
OWN - NLM
STAT- MEDLINE
DCOM- 20030530
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 192
IP  - 2
DP  - 2003 Mar 31
TI  - Relationship between dendritic cells and the D-fraction-induced Th-1 dominant 
      response in BALB/c tumor-bearing mice.
PG  - 181-7
AB  - Dendritic cells (DCs) are known to not only induce the activation of T cells, but 
      are also associated with the differentiation of T cells. The D-fraction, a 
      beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor 
      effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced 
      IL-12p70 production by DCs, when the ratio of CD8alpha(+) DCs to CD8alpha(-) DCs 
      increased. In addition, examination of the tumor rejection effect of 
      D-fraction-stimulated DCs loaded with tumor antigen revealed that tumor growth is 
      inhibited completely by activating CD4(+) T cells and CD8(+) T cells.
FAU - Harada, Nachi
AU  - Harada N
AD  - Department of Microbial Chemistry, Kobe Pharmaceutical University, 4-19-1, 
      Motoyama-kitamachi, Higashinada-ku, 658-8558, Kobe, Japan.
FAU - Kodama, Noriko
AU  - Kodama N
FAU - Nanba, Hiroaki
AU  - Nanba H
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Agaricales/chemistry
MH  - Animals
MH  - Antigens, Neoplasm/immunology
MH  - Cell Differentiation/drug effects
MH  - Cell Division
MH  - Colonic Neoplasms/*immunology/pathology
MH  - Dendritic Cells/cytology/*drug effects/*immunology/metabolism
MH  - Female
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/*pharmacology
MH  - Th1 Cells/cytology/*drug effects/*immunology
MH  - Time Factors
EDAT- 2003/04/02 05:00
MHDA- 2003/05/31 05:00
CRDT- 2003/04/02 05:00
PHST- 2003/04/02 05:00 [pubmed]
PHST- 2003/05/31 05:00 [medline]
PHST- 2003/04/02 05:00 [entrez]
AID - S0304383502007164 [pii]
AID - 10.1016/s0304-3835(02)00716-4 [doi]
PST - ppublish
SO  - Cancer Lett. 2003 Mar 31;192(2):181-7. doi: 10.1016/s0304-3835(02)00716-4.