PMID- 12670833
OWN - NLM
STAT- MEDLINE
DCOM- 20030718
LR  - 20151119
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 285
IP  - 1
DP  - 2003 Jul
TI  - Estrogen promotes microvascular pathology in female stroke-prone spontaneously 
      hypertensive rats.
PG  - E232-9
AB  - Estrogen produces both beneficial and adverse effects on cardiovascular health 
      via mechanisms that remain unclear. Stroke-prone spontaneously hypertensive rats 
      (SHRSP) maintained on Stroke-Prone Rodent Diet and 1% NaCl drinking water 
      (starting at 8 wk of age) rapidly develop stroke and malignant nephrosclerosis 
      that can be prevented, despite continued hypertension, by drugs targeting 
      angiotensin II and aldosterone actions. This study evaluated estrogen's effects 
      in the SHRSP model. Female SHRSP that were sham operated (SHAM), ovariectomized 
      (OVX) at 4 wk of age, or OVX and treated with estradiol benzoate (E2,30 microg x 
      kg-1 x wk-1) were studied. In a survival protocol, OVX rats lived significantly 
      longer (15.1 +/- 0.3 wk) compared with SHAM (13.6 +/- 0.2 wk) or OVX+E2 rats 
      (12.4 +/- 0.2 wk). In a protocol in which animals were matched for age, at 11.5 
      wk, terminal systolic blood pressure and urine protein excretion were elevated in 
      SHAM and OVX+E2 rats compared with OVX rats; blood urea nitrogen, renal 
      microvascular and glomerular lesions, and plasma renin concentration were 
      elevated in OVX+E2 relative to SHAM or OVX rats. In a survival protocol using 
      intact female SHRSP, treatment with an antiestrogen (tamoxifen, 7 mg.kg-1.wk-1) 
      prolonged survival by >2 wk compared with controls (P < 0.01). The data indicate 
      that estrogen promotes microangiopathy in the kidney and stroke in 
      saline-drinking SHRSP.
FAU - Stier, Charles T Jr
AU  - Stier CT Jr
AD  - Department of Pharmacology, New York Medical College, Valhalla 10595, USA. 
      charles_stier@nymc.edu
FAU - Chander, Praveen N
AU  - Chander PN
FAU - Rosenfeld, Louis
AU  - Rosenfeld L
FAU - Powers, C Andrew
AU  - Powers CA
LA  - eng
GR  - DK-32783/DK/NIDDK NIH HHS/United States
GR  - HL-35522/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20030401
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Estrogen Antagonists)
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 094ZI81Y45 (Tamoxifen)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 4TI98Z838E (Estradiol)
RN  - 9041-90-1 (Angiotensin I)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin I/blood
MH  - Animals
MH  - Blood Pressure/genetics/physiology
MH  - Body Weight/genetics
MH  - Capillaries/drug effects/growth & development
MH  - Estradiol/*analogs & derivatives/pharmacology
MH  - Estrogen Antagonists/pharmacology
MH  - Estrogen Replacement Therapy
MH  - Estrogens/*pharmacology
MH  - Female
MH  - Kidney/pathology
MH  - Neovascularization, Pathologic/*chemically induced/pathology
MH  - Organ Size/genetics
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Receptors, Estrogen/antagonists & inhibitors
MH  - Renin/blood
MH  - Sodium Chloride
MH  - Stimulation, Chemical
MH  - Stroke/*genetics/*pathology
MH  - Survival Analysis
MH  - Tamoxifen/pharmacology
EDAT- 2003/04/03 05:00
MHDA- 2003/07/19 05:00
CRDT- 2003/04/03 05:00
PHST- 2003/04/03 05:00 [pubmed]
PHST- 2003/07/19 05:00 [medline]
PHST- 2003/04/03 05:00 [entrez]
AID - 00029.2003 [pii]
AID - 10.1152/ajpendo.00029.2003 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E232-9. doi: 
      10.1152/ajpendo.00029.2003. Epub 2003 Apr 1.