PMID- 12671736
OWN - NLM
STAT- MEDLINE
DCOM- 20030523
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 54
IP  - 12
DP  - 2003 Mar
TI  - Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage 
      after the separation of the human and chimpanzee species.
PG  - 856-61
AB  - Conventional phylogenetic trees for the human leukocyte antigen (HLA)-DRB1 
      alleles constructed by the neighbor-joining (Saitou and Nei 1987) and UPGMA 
      (Sneath and Sokal 1973) methods using nucleotide sequences of the DRB1 alleles 
      suggest that DRB1*0701 may have diverged from other DRB1 alleles before the 
      separation of the human and chimpanzee species, because of a large number of 
      nucleotide changes in DRB1*0701 compared with any of the other DRB1 alleles. Here 
      we show new evidence that the haplotypes centering on DRB1*0701 and DRB1*04 
      alleles are the most homologous. This suggests that these haplotypes have derived 
      from the common ancestral haplotype, and that they have likely retained complete 
      linkage disequilibrium even after the divergence of the DRB1*0701 and DRB1*04 
      allelic lineages. Together with the corresponding haplotype carrying chimpanzee 
      DRB1*0701, which has a high sequence homology to HLA-DRB1*0701, these haplotypes 
      reveal that: (1) the DRB1*04 allelic lineage may have been generated from the 
      DRB1*0701 lineage after the separation of the human and chimpanzee species; (2) 
      the DRB1*04 allelic lineage possibly has a higher substitution rate of DRB1 
      compared with pseudogene and neutral region; (3) there could be a significant 
      difference in the substitution rate of DRB1 between the DRB1*0701 and DRB1*04 
      allelic lineages. Based on the difference between the present and previous 
      results, we would like to propose that phylogenetic studies using not only 
      nucleotide sequences of the DRB1 alleles but also haplotypes centering on the 
      alleles should be conducted for understanding detailed phylogenetic relationships 
      of the DRB1 alleles.
FAU - Hohjoh, Hirohiko
AU  - Hohjoh H
AD  - Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 
      Tokyo, Japan. hohjohh@ncnp.go.jp
FAU - Ohashi, Jun
AU  - Ohashi J
FAU - Takasu, Miwa
AU  - Takasu M
FAU - Nishioka, Tomoki
AU  - Nishioka T
FAU - Ishida, Takafumi
AU  - Ishida T
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030307
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Base Sequence
MH  - DNA/genetics
MH  - *Evolution, Molecular
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Models, Genetic
MH  - Pan troglodytes/*genetics/*immunology
MH  - Phylogeny
MH  - Pseudogenes
MH  - Species Specificity
EDAT- 2003/04/03 05:00
MHDA- 2003/05/24 05:00
CRDT- 2003/04/03 05:00
PHST- 2002/11/22 00:00 [received]
PHST- 2003/01/08 00:00 [revised]
PHST- 2003/04/03 05:00 [pubmed]
PHST- 2003/05/24 05:00 [medline]
PHST- 2003/04/03 05:00 [entrez]
AID - 10.1007/s00251-003-0539-z [doi]
PST - ppublish
SO  - Immunogenetics. 2003 Mar;54(12):856-61. doi: 10.1007/s00251-003-0539-z. Epub 2003 
      Mar 7.