PMID- 12672617
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20190910
IS  - 0378-5173 (Print)
IS  - 0378-5173 (Linking)
VI  - 255
IP  - 1-2
DP  - 2003 Apr 14
TI  - A new model for predicting moisture uptake by packaged solid pharmaceuticals.
PG  - 217-25
AB  - A novel mathematical model has been developed for predicting moisture uptake by 
      packaged solid pharmaceutical products during storage. High density polyethylene 
      (HDPE) bottles containing the tablet products of two new chemical entities and 
      desiccants are investigated. Permeability of the bottles is determined at 
      different temperatures using steady-state data. Moisture sorption isotherms of 
      the two model drug products and desiccants at the same temperatures are 
      determined and expressed in polynomial equations. The isotherms are used for 
      modeling the time-humidity profile in the container, which enables the prediction 
      of the moisture content of individual component during storage. Predicted 
      moisture contents agree well with real time stability data. The current model 
      could serve as a guide during packaging selection for moisture protection, so as 
      to reduce the cost and cycle time of screening study.
FAU - Chen, Y
AU  - Chen Y
AD  - Abbott Laboratories, Global Pharmaceutical R&D, R4P7, 1401 Sheridan Road, North 
      Chicago, IL 60064, USA. yisheng.chen@abbott.com
FAU - Li, Y
AU  - Li Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Tablets)
RN  - 059QF0KO0R (Water)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Absorption
MH  - Algorithms
MH  - Desiccation
MH  - *Drug Packaging
MH  - Drug Storage
MH  - Humidity
MH  - *Models, Chemical
MH  - Permeability
MH  - *Polyethylene/chemistry
MH  - Tablets
MH  - Temperature
MH  - Water
EDAT- 2003/04/04 05:00
MHDA- 2003/09/17 05:00
CRDT- 2003/04/04 05:00
PHST- 2003/04/04 05:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/04/04 05:00 [entrez]
AID - S0378517303000899 [pii]
AID - 10.1016/s0378-5173(03)00089-9 [doi]
PST - ppublish
SO  - Int J Pharm. 2003 Apr 14;255(1-2):217-25. doi: 10.1016/s0378-5173(03)00089-9.