PMID- 12673036
OWN - NLM
STAT- MEDLINE
DCOM- 20031121
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 26
IP  - 4
DP  - 2003 Apr
TI  - Effects of (+)-catechin on the function of osteoblastic cells.
PG  - 523-6
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are candidate 
      cytokines which are produced by osteoblastic linage cells and promote osteoblast 
      apoptosis, osteoclastogenesis and bone resorption. Here, we examined the effect 
      of (+)-catechin, one of the most common grape flavonols, on osteoblastic MC3T3-E1 
      cells. (+)-Catechin caused a significant elevation of cell survival at 10(-5) and 
      10(-4) M and alkaline phosphatase activity at 10(-5) M. Also, treatment with 
      (+)-catechin (10(-5) M) decreased bone-resorbing cytokines (TNF-alpha and IL-6) 
      production and apoptosis in osteoblasts. Our data indicate that the reduction of 
      bone-resorbing cytokines and apoptosis in osteoblasts by (+)-catechin may result 
      in the prevention and therapy for osteoporosis and inflammatory bone diseases.
FAU - Choi, Eun-Mi
AU  - Choi EM
AD  - Department of Biotechnology & Bioproducts Research Center, Yonsei University, 
      Seoul, Korea.
FAU - Hwang, Jae-Kwan
AU  - Hwang JK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 8R1V1STN48 (Catechin)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/physiology
MH  - Catechin/*pharmacology
MH  - Cell Line
MH  - Cell Survival/drug effects/physiology
MH  - Interleukin-6/biosynthesis
MH  - Mice
MH  - Osteoblasts/*drug effects/*physiology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2003/04/04 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/04/04 05:00
PHST- 2003/04/04 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/04/04 05:00 [entrez]
AID - 10.1248/bpb.26.523 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2003 Apr;26(4):523-6. doi: 10.1248/bpb.26.523.