PMID- 12674764
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20240202
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 22
IP  - 4
DP  - 2002
TI  - Effect of Salvia miltiorrhiza on left ventricular hypertrophy and cardiac 
      aldosterone in spontaneously hypertensive rats.
PG  - 302-4
AB  - Chronic treatment with Salvia Miltiorrhiza preventing left ventricular 
      hypertrophy (LVH) and its possible mechanism--inhibiting the action of cardiac 
      aldosterone in spontaneously hypertensive rats (SHR) were investigated. 
      Normotensive Wistar-kyoto (WKY) rats and SHRs were used. Part of SHRs was treated 
      with Salvia Miltiorrhiza for 12 weeks. Systolic blood pressure (SBP) and left 
      ventricular mass index were measured. Sections of heart tissue were stained with 
      HE method and VanGieson method. Collagen volume fraction was determined in the 
      left ventricle by automatically quantitative morphometry. Cardiac aldosterone 
      concentration was measured by radioimmunoassay. The results indicated that 
      compared with WKY rats, SHRs exhibited higher SBP, left ventricular collagen 
      volume fraction, and aldosterone concentration (all P < 0.05). After the 
      treatment with Salvia Miltiorrhiza, SBP, left ventricular collagen volume 
      fraction, and aldosterone concentration in SHR were decreased as compared with 
      control group (P < 0.05) except SBP. It was concluded that chronic treatment with 
      Salvia Miltiorrhiza could prevent left ventricular hypertrophy in SHR, 
      significantly inhibit collagen compositions in left ventricle. The mechanism was 
      probably related with the inhibition of the cardiac aldosterone action.
FAU - Han, Shaojie
AU  - Han S
AD  - Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030.
FAU - Zheng, Zhi
AU  - Zheng Z
FAU - Ren, Dahong
AU  - Ren D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Drugs, Chinese Herbal)
RN  - 4964P6T9RB (Aldosterone)
SB  - IM
MH  - Aldosterone/*metabolism
MH  - Animals
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Hypertension/metabolism/*physiopathology
MH  - Hypertrophy, Left Ventricular/*metabolism/prevention & control
MH  - Male
MH  - Myocardium/metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - *Salvia miltiorrhiza
EDAT- 2003/04/05 05:00
MHDA- 2004/07/21 05:00
CRDT- 2003/04/05 05:00
PHST- 2003/04/05 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2003/04/05 05:00 [entrez]
AID - 10.1007/BF02896770 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2002;22(4):302-4. doi: 10.1007/BF02896770.