PMID- 12677185
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0214-0934 (Print)
IS  - 0214-0934 (Linking)
VI  - 15
IP  - 8
DP  - 2002 Oct
TI  - Role of Cytokines and Chemokines in Renal Ischemia-Reperfusion Injury.
PG  - 477-482
AB  - Cytokines and chemokines produced by renal tubular epithelial cells and 
      infiltrated cells are critical factors in inflammatory processes of renal 
      ischemia-reperfusion injury. In vitro studies reveal that renal tubular 
      epithelial cells have the potential to produce diverse cytokines, chemokines and 
      other mediators, such as tumor necrosis factor-alpha, interleukin-1 (IL-1), 
      monocyte chemoattractant protein-1, IL-8, platelet-derived growth factor, 
      regulated upon activation, normal T cell expressed and secreted, endothelin-1 and 
      vascular endothelial growth factor (VEGF). Huge numbers of in vivo studies show 
      that cytokines, chemokines and adhesion molecules in diseased kidney together 
      govern critical aspects of ischemia-reperfusion injury. Leukocyte-endothelial 
      cell interactions are critical processes of leukocytic infiltration, which are 
      pathologically key factors in inflammatory processes of renal 
      ischemia-reperfusion injury. Leukocyte-endothelial interactions are regulated by 
      a cascade of molecular steps of cytokines, chemokines and adhesion molecules. In 
      contrast, the intracellular cascades of cytokine and chemokine expression in the 
      renal ischemia-reperfusion injury remain to be investigated. p38 
      mitogen-activated protein kinase is one of the essential mediators in cytokine 
      and chemokine expression through the activation of nuclear factor-kappaB and 
      activating protein-1. Moreover, hypoxia-inducible factor-1 (HIF-1) is a 
      transcription factor activated by reductions in oxygen concentration. 
      HIF-1-related gene expression, such as erythropoietin or VEGF, results in 
      protection of ischemia reperfusion injury. This review focuses on the 
      contribution of cytokines, chemokines and their related molecules to the 
      inflammatory cascade in renal ischemia-reperfusion injury. (c) 2002 Prous 
      Science. All rights reserved.
FAU - Furuichi, Kengo
AU  - Furuichi K
FAU - Wada, Takashi
AU  - Wada T
FAU - Yokoyama, Hitoshi
AU  - Yokoyama H
FAU - Kobayashi, Ken-Ichi
AU  - Kobayashi KI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Drug News Perspect
JT  - Drug news & perspectives
JID - 8809164
EDAT- 2003/04/05 05:00
MHDA- 2003/04/05 05:01
CRDT- 2003/04/05 05:00
PHST- 2003/04/05 05:00 [pubmed]
PHST- 2003/04/05 05:01 [medline]
PHST- 2003/04/05 05:00 [entrez]
AID - 329 [pii]
AID - 10.1358/dnp.2002.15.8.840067 [doi]
PST - ppublish
SO  - Drug News Perspect. 2002 Oct;15(8):477-482. doi: 10.1358/dnp.2002.15.8.840067.