PMID- 12678533
OWN - NLM
STAT- MEDLINE
DCOM- 20030516
LR  - 20081121
IS  - 1028-5229 (Print)
IS  - 1028-5229 (Linking)
VI  - 2
IP  - 4
DP  - 2000
TI  - Monitoring the metabolic response to major surgery in neonates.
PG  - 309-12
AB  - BACKGROUND: Visceral proteins and acute phase reactants have commonly been used 
      as indicators of nutritional status, and metabolic response of surgical trauma. 
      AIM: This study was undertaken to determine how some plasma proteins, alone or 
      together reflect metabolic response in neonates recovering from major surgery. 
      METHODS: Serum albumin, pre-albumin (PA), C-reactive protein (CRP), and 
      alpha1-acid glycoprotein (AGP) levels were measured, and the prognostic 
      inflammatory and nutritional index (PINI) was calculated for preoperative day 1 
      (-1) and postoperative (PO) days 1 (+1) and 7 (+7). RESULTS: PA, CRP, AGP and 
      PINI were significantly different on day +1 from day -1. While AGP and PINI were 
      still significantly higher than that of day -1, PA and CRP returned to the 
      preoperative levels on day +7. CONCLUSION: PA, CRP and AGP measurements are 
      superior to PINI for assessing postoperative metabolic changes in term neonates 
      following uncomplicated major surgery on early and late phase. But this 
      comparison must be performed in the management of more complex cases to determine 
      which one is better to indicate morbidity and mortality.
FAU - Caglayan, F
AU  - Caglayan F
AD  - Department of Pediatric Surgery, Medical Faculty, Kirikkale University, 71100 
      Kirikkale, Turkey. fatmacaglayan@yahoo.com
FAU - Caglayan, O
AU  - Caglayan O
FAU - Gunel, E
AU  - Gunel E
FAU - Sahin, T K
AU  - Sahin TK
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Int J Surg Investig
JT  - International journal of surgical investigation
JID - 100965774
RN  - 0 (Blood Proteins)
SB  - IM
MH  - Anesthesia, General
MH  - Blood Proteins/*metabolism
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Stress, Physiological
MH  - *Surgical Procedures, Operative
EDAT- 2003/04/08 05:00
MHDA- 2003/05/17 05:00
CRDT- 2003/04/08 05:00
PHST- 2003/04/08 05:00 [pubmed]
PHST- 2003/05/17 05:00 [medline]
PHST- 2003/04/08 05:00 [entrez]
PST - ppublish
SO  - Int J Surg Investig. 2000;2(4):309-12.