PMID- 12679783
OWN - NLM
STAT- MEDLINE
DCOM- 20030701
LR  - 20220309
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 6
IP  - 5
DP  - 2003 May
TI  - Modal gating of NMDA receptors and the shape of their synaptic response.
PG  - 476-83
AB  - N-methyl-D-aspartate receptor (NMDAR) channels mediate the slow component of 
      excitatory potentials at glutamatergic synapses. They have complex kinetic 
      behavior, and much remains to be understood about NMDAR gating mechanisms and the 
      molecular events that shape the synaptic current. Here we show that an individual 
      NMDAR produces at least three stable patterns of activity. For all modes, 
      channels gate by the same mechanism and can occupy either of two open states. The 
      relative stability of the open states differs across modes because of a common 
      perturbation to the NMDAR structure that may be subject to cellular control. 
      Simulations indicate that native NMDAR-mediated synaptic responses arise mainly 
      from the most common mode, and that the slow rise and decay of the current can be 
      attributed to multiple transitions between fully liganded open and closed states 
      rather than to agonist dissociation.
FAU - Popescu, Gabriela
AU  - Popescu G
AD  - Center for Single Molecule Biophysics and the Department of Physiology and 
      Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, 
      Buffalo, New York 14214, USA. popescu@buffalo.edu
FAU - Auerbach, Anthony
AU  - Auerbach A
LA  - eng
GR  - F32 DA015164/DA/NIDA NIH HHS/United States
GR  - DA015164/DA/NIDA NIH HHS/United States
GR  - NS036554/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Humans
MH  - Ion Channel Gating/drug effects/*physiology
MH  - *Models, Biological
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/agonists/*physiology
MH  - Synapses/drug effects/*physiology
EDAT- 2003/04/08 05:00
MHDA- 2003/07/02 05:00
CRDT- 2003/04/08 05:00
PHST- 2002/12/02 00:00 [received]
PHST- 2003/03/11 00:00 [accepted]
PHST- 2003/04/08 05:00 [pubmed]
PHST- 2003/07/02 05:00 [medline]
PHST- 2003/04/08 05:00 [entrez]
AID - nn1044 [pii]
AID - 10.1038/nn1044 [doi]
PST - ppublish
SO  - Nat Neurosci. 2003 May;6(5):476-83. doi: 10.1038/nn1044.