PMID- 12680651
OWN - NLM
STAT- MEDLINE
DCOM- 20030530
LR  - 20190522
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 14
IP  - 1
DP  - 2002 Jan
TI  - Failure of porcine reproductive and respiratory syndrome virus to replicate in 
      porcine endothelial cell cultures.
PG  - 73-6
AB  - Clinical, gross, and microscopic pathologic and immunohistochemical findings in 
      pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) 
      suggest that PRRSV may replicate in endothelial cells. Endothelial cell cultures 
      from porcine aorta and pulmonary artery were tested for susceptibility to various 
      strains of PRRSV. Cultures were identified as endothelium by light microscopy and 
      immunohistochemical staining for P-selectin and von Willebrand factor. Five 
      strains of PRRSV, i.e., the National Veterinary Services Laboratories, Ames, IA 
      PRRSV strain 130-PDV and 4 field strains isolated from pneumonic lungs, failed to 
      replicate in these porcine large-vessel endothelial cell cultures.
FAU - Howerth, E W
AU  - Howerth EW
AD  - Department of Pathology, College of Veterinary Medicine, University of Georgia, 
      Athens, GA 30602, USA.
FAU - Murphy, M D
AU  - Murphy MD
FAU - Roberts, A W
AU  - Roberts AW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - Animals
MH  - Aorta/cytology
MH  - Cell Culture Techniques
MH  - Endothelium, Vascular/*cytology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Pulmonary Artery/cytology
MH  - *Swine
MH  - *Virus Replication
EDAT- 2003/04/12 05:00
MHDA- 2003/05/31 05:00
CRDT- 2003/04/12 05:00
PHST- 2003/04/12 05:00 [pubmed]
PHST- 2003/05/31 05:00 [medline]
PHST- 2003/04/12 05:00 [entrez]
AID - 10.1177/104063870201400117 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 2002 Jan;14(1):73-6. doi: 10.1177/104063870201400117.