PMID- 12681098
OWN - NLM
STAT- MEDLINE
DCOM- 20030605
LR  - 20201208
IS  - 0025-7753 (Print)
IS  - 0025-7753 (Linking)
VI  - 120
IP  - 10
DP  - 2003 Mar 22
TI  - [Phenotypes of resistance in community urinary tract isolates of Escherichia 
      coli: therapeutic implications].
PG  - 361-4
AB  - BACKGROUND AND OBJECTIVE: Urinary tract infectious (UTI) are very frequent in the 
      community and are managed through empirical treatment guidelines. The knowledge 
      of patterns of susceptibility of patients at the time of establishing an 
      empirical treatment is fundamental to avoid therapeutic failures. The aim of this 
      study was to know the pattern of resistance to betalactams and other 
      antimicrobials used in the treatment of non-complicated urinary infections in the 
      area 11 of Madrid. PATIENTS AND METHOD: Retrospective study of susceptibility of 
      Escherichia coli isolated in cultures of urine of outpatients of area 11 of 
      Madrid during a period of 12 months. RESULTS: We found high rates of resistance 
      to ampicillin and trimethoprim-sulfamethoxazole (57 and 29%, respectively). We 
      observed high rates of resistance to cefuroxime (24%) and amoxicillin-clavulanic 
      acid (27%). Resistance to ciprofloxacine was 16%. Resistance to phosphomicin and 
      nitrofurantoin was very low (5 and 4%). Most frequent resistance association was 
      ampicillin + cephalothin (20,2%). The mechanisms of resistance having more 
      clinical relevance was the production and hyper-production of betalactamase. 
      CONCLUSIONS: Changes were detected as to the pattern of susceptibility of certain 
      antimicrobials frequently used in the empirical treatment of UTI such as 
      cefuroxime and amoxicillin-clavulanic acid. It is important to support a 
      condition of active surveillance for the evolution of resistances.
FAU - Alonso Sanz, Mercedes
AU  - Alonso Sanz M
AD  - Laboratorio de Analisis Clinicos. Departamento de Microbiologia. CEP. 
      Carabanchel. Area 11. Madrid. Espana. malonso@hdoc.insalud.es
FAU - Abad Becquer, M Isabel
AU  - Abad Becquer MI
LA  - spa
PT  - Journal Article
TT  - Fenotipos de resistencia en aislamientos urinarios de Escherichia coli en la 
      comunidad: implicaciones terapeuticas.
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
SB  - IM
MH  - Community-Acquired Infections
MH  - *Drug Resistance, Bacterial
MH  - Escherichia coli/*drug effects
MH  - Escherichia coli Infections/drug therapy/*microbiology
MH  - Humans
MH  - Spain
MH  - Urinary Tract Infections/drug therapy/*microbiology
MH  - beta-Lactam Resistance
EDAT- 2003/04/12 05:00
MHDA- 2003/06/06 05:00
CRDT- 2003/04/12 05:00
PHST- 2003/04/12 05:00 [pubmed]
PHST- 2003/06/06 05:00 [medline]
PHST- 2003/04/12 05:00 [entrez]
AID - S0025-7753(03)73705-1 [pii]
AID - 10.1016/s0025-7753(03)73705-1 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2003 Mar 22;120(10):361-4. doi: 10.1016/s0025-7753(03)73705-1.