PMID- 12681453
OWN - NLM
STAT- MEDLINE
DCOM- 20030424
LR  - 20190627
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 114
IP  - 4
DP  - 2003 Mar
TI  - Functional class in patients with heart failure is associated with the 
      development of diabetes.
PG  - 271-5
AB  - PURPOSE: Recent reports suggest that decreased functional capacity in patients 
      with heart failure may be associated with abnormalities in glucose metabolism. We 
      followed patients with coronary artery disease who participated in the 
      Bezafibrate Infarction Prevention study to determine the incidence of diabetes by 
      baseline functional status during a 7.7-year follow-up. METHODS: The sample 
      comprised 2616 nondiabetic patients aged 45 to 74 years with a fasting blood 
      glucose level <7 mmol/L (126 mg/dL). They were divided into three groups by New 
      York Heart Association (NYHA) criteria: class I (n = 1986 patients), class II (n 
      = 518), and class III (n = 112). The detection of a fasting blood glucose level > 
      or =7 mmol/L during follow-up was defined as the criterion for the development of 
      diabetes. RESULTS: The study groups had similar demographic and clinical 
      characteristics, except that patients with symptomatic heart failure (NYHA class 
      II or III) were more likely to have angina. During follow-up, diabetes developed 
      in 259 patients (13%) in NYHA class I, 76 (15%) in class II, and 22 (20%) in 
      class III (P for trend = 0.05). At the last visit, patients in NYHA class III 
      were twice as likely (17% [n = 19]) to have fasting blood glucose levels > or =7 
      mmol/L as those in NYHA class I (7.8% [n = 154]) or class II (8.7% [n = 45]) (P = 
      0.005). In a multivariate analysis, NYHA class III was associated with a 1.7-fold 
      (95% confidence interval [CI]: 1.1 to 2.6) increase in the rate of development of 
      diabetes, but NYHA class II was not (hazard ratio = 1.0; 95% CI: 0.8 to 1.3). 
      CONCLUSION: Among patients with coronary artery disease, advanced heart failure 
      (NYHA class III) is associated with a significantly increased risk of developing 
      diabetes during a 6- to 9-year follow-up.
FAU - Tenenbaum, Alexander
AU  - Tenenbaum A
AD  - Cardiac Rehabilitation Institute, Neufeld Cardiac Research Institute, the Chaim 
      Sheba Medical Center, Tel-Hashomer, 52621 Israel. altenen@yahoo.com
FAU - Motro, Michael
AU  - Motro M
FAU - Fisman, Enrique Z
AU  - Fisman EZ
FAU - Leor, Jonathan
AU  - Leor J
FAU - Freimark, Dov
AU  - Freimark D
FAU - Boyko, Valentina
AU  - Boyko V
FAU - Mandelzweig, Lori
AU  - Mandelzweig L
FAU - Adler, Yehuda
AU  - Adler Y
FAU - Sherer, Yaniv
AU  - Sherer Y
FAU - Behar, Solomon
AU  - Behar S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
SB  - IM
CIN - Am J Med. 2003 Mar;114(4):331-2. PMID: 12681465
CIN - Am J Med. 2003 Oct 1;115(5):412; author reply 412. PMID: 14553881
MH  - Age Distribution
MH  - Aged
MH  - Cohort Studies
MH  - Comorbidity
MH  - Confidence Intervals
MH  - Coronary Disease/*classification/diagnosis/*epidemiology
MH  - Diabetes Mellitus/diagnosis/*epidemiology
MH  - Female
MH  - Heart Failure/*classification/diagnosis/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Probability
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Survival Analysis
EDAT- 2003/04/12 05:00
MHDA- 2003/04/25 05:00
CRDT- 2003/04/12 05:00
PHST- 2003/04/12 05:00 [pubmed]
PHST- 2003/04/25 05:00 [medline]
PHST- 2003/04/12 05:00 [entrez]
AID - S0002934302015309 [pii]
AID - 10.1016/s0002-9343(02)01530-9 [doi]
PST - ppublish
SO  - Am J Med. 2003 Mar;114(4):271-5. doi: 10.1016/s0002-9343(02)01530-9.