PMID- 12686273
OWN - NLM
STAT- MEDLINE
DCOM- 20030624
LR  - 20190922
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 114
IP  - 4
DP  - 2003 Apr
TI  - Abnormal cutaneomotor integration in patients with cerebellar syndromes: a 
      transcranial magnetic stimulation study.
PG  - 643-51
AB  - OBJECTIVE: To examine the sensorimotor interactions in cerebellar patients. 
      METHODS: We investigated the effects of electrical stimulation of the second (D2) 
      and fifth (D5) fingers on the amplitude of motor evoked potentials (MEPs) in 
      response to transcranial magnetic stimulation and transcranial electrical 
      stimulation (TES) in the relaxed right abductor digiti minimi muscles of 7 
      patients with cerebellar syndromes and of 14 age-matched controls. The digital 
      stimulation was set at 3 times the sensory threshold and preceded brain 
      stimulation at interstimulus intervals (ISIs) ranging from 10 to 100 ms. RESULTS: 
      D5 stimulation produced significant MEP inhibition in normal subjects at ISIs of 
      20-50 ms, while D2 stimulation resulted in a non-significant inhibitory trend 
      with the same intervals. In contrast, digital stimulation had no effect on MEP 
      amplitude in cerebellar patients. A significant difference was found between 
      patients and controls at ISIs of 20-50 ms with D5 stimulation. The difference in 
      amplitude of MEPs conditioned by D5 and D2 stimulation was statistically 
      significant between patients and controls at ISIs of 30 and 50 ms. TES 
      conditioning induced MEP inhibition only at ISIs <40 ms. CONCLUSIONS: Digital 
      stimulation would appear to modulate motor system excitability less effectively 
      in cerebellar patients. MEP inhibition by cutaneous afferences is reduced in 
      response to stimulation of contiguous, as well as non-contiguous fingers. The 
      difference between the conditioning effects of the two fingers is also decreased, 
      and therefore the somatotopic distribution of cutaneomotor inhibition is absent 
      in patients. These abnormalities may contribute to the genesis of cerebellar 
      motor symptoms and their time course suggests involvement of subcortical and 
      cortical sites.
FAU - Tamburin, Stefano
AU  - Tamburin S
AD  - Section of Neurological Rehabilitation, Department of Neurological Sciences and 
      Vision, University of Verona, Verona, Italy. s_tamburin@yahoo.com 
      <s_tamburin@yahoo.com>
FAU - Fiaschi, Antonio
AU  - Fiaschi A
FAU - Andreoli, Annalisa
AU  - Andreoli A
FAU - Forgione, Antonio
AU  - Forgione A
FAU - Manganotti, Paolo
AU  - Manganotti P
FAU - Zanette, Giampietro
AU  - Zanette G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Cerebellar Ataxia/*physiopathology
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Fingers/innervation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Neurons/physiology
MH  - Muscle, Skeletal/innervation
MH  - Neural Inhibition/physiology
MH  - Neurons, Afferent/physiology
MH  - Skin/innervation
MH  - *Transcranial Magnetic Stimulation
EDAT- 2003/04/11 05:00
MHDA- 2003/06/25 05:00
CRDT- 2003/04/11 05:00
PHST- 2003/04/11 05:00 [pubmed]
PHST- 2003/06/25 05:00 [medline]
PHST- 2003/04/11 05:00 [entrez]
AID - S1388245703000026 [pii]
AID - 10.1016/s1388-2457(03)00002-6 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2003 Apr;114(4):643-51. doi: 10.1016/s1388-2457(03)00002-6.