PMID- 12687138
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1028-7221 (Print)
IS  - 1028-7221 (Linking)
VI  - 4
IP  - 3
DP  - 1999 Oct
TI  - Knowledge on Allergic Inflammation - the Basis for Solving the Problem of 
      Bronchial Asthma.
PG  - 257-260
AB  - The manifestations of allergen-specific IgE-mediated reactions constitute the 
      basis of allergic inflammation as universal specialized form of recognition of 
      allergen entered the body and organization of response reaction in relation to 
      this foreign agent. The stage of induction of special type of immune response by 
      the body entered allergen is a decisive one in the chain of replaceable events 
      terminated by external signs of allergy. This response results in the formation 
      of allergic antibodies that belong to immunoglobulin E (IgE) which are fixed on 
      inflammatory cells, "arming" them by specific mechanism of recognition of new 
      body entering allergen. The main cell representatives of allergic inflammation 
      are mast cells, basophils, eosinophils, as well as lymphoid and epithelial cells. 
      These cells are involved in response in different time intervals after allergen 
      action on sensibilized (due to allergen-specific IgE) respiratory mucosa. 
      Therefore, sequential involvement of these cells in allergic process gives early, 
      at first, and then late phases of allergic reaction. "Arming" of mucosa by 
      allergen-recognizing mechanism is providing by fixation of allergen-specific IgE 
      on high affinity receptors for this immunoglobulin (Fcepsilon-receptors type I - 
      FcepsilonRI), expressed on mast cells. The involvement in the process of 
      additional cells-participants of allergic response, forming the late phase is 
      mediated by mechanisms that may be induced during early phase by mast cell 
      mediators.
FAU - Guschin, Igor S
AU  - Guschin IS
AD  - State Scientific Center - Institute of Immunology, Moscow, Russia.
LA  - eng
PT  - Journal Article
PL  - Russia (Federation)
TA  - Russ J Immunol
JT  - Russian journal of immunology : RJI : official journal of Russian Society of 
      Immunology
JID - 9713940
EDAT- 2003/04/11 05:00
MHDA- 2003/04/11 05:00
CRDT- 2003/04/11 05:00
PHST- 2003/04/11 05:00 [pubmed]
PHST- 2003/04/11 05:00 [medline]
PHST- 2003/04/11 05:00 [entrez]
AID - 00499257 [pii]
PST - ppublish
SO  - Russ J Immunol. 1999 Oct;4(3):257-260.