PMID- 12688183
OWN - NLM
STAT- MEDLINE
DCOM- 20030424
LR  - 20091111
IS  - 0036-5327 (Print)
IS  - 0036-5327 (Linking)
VI  - 103
IP  - 3
DP  - 2002
TI  - [Kidney involvement in light-chain deposition disease].
PG  - 397-403
AB  - An overview concerning different types of kidney involvement associated with 
      monoclonal gammapathy (MG) is given, focused on light-chain deposition disease 
      (LCDD). Pathophysiologic basis of LCDD remains in the light-chain tissue 
      deposition (resp. in tissue deposition of immunoglobulin's stable domain). This 
      mechanism is typical for monoclonal immunoglobulin's overproduction as found in 
      MG. Clinical picture of LCDD reflects multiorgan character of disorder, while 
      renal lesions rank among the most frequent, serious and best documented ones. 
      Clinical data referring to a group of six patients, treated in our nephrologic 
      department are presented. Diagnosis of LCDD was established on basis of the renal 
      biopsy finding. Renal functions were decreased at the time of diagnosis in all 
      patients, whereas haemodialysis treatment was started in one patient. On 
      conclusion therapeutic possibilities of LCDD are discussed, in which number 
      symptomatic therapy of renal failure is combined with corticosteroids therapy and 
      cytostatic therapy; prognosis of most patients remains serious.
FAU - Merta, M
AU  - Merta M
AD  - I. interni klinika 1. lekarske fakulty Univerzity Karlovy a Vseobecne fakultni 
      nemocnice, U nemocnice 2, 128 08 Praha 2, Czech Republic. merta@mbox.cesnet.cz
FAU - Rysava, R
AU  - Rysava R
FAU - Zabka, J
AU  - Zabka J
FAU - Stejskalova, A
AU  - Stejskalova A
FAU - Vernerova, Z
AU  - Vernerova Z
FAU - Haber, J
AU  - Haber J
FAU - Spicka, I
AU  - Spicka I
FAU - Tesar, V
AU  - Tesar V
FAU - Klener, P
AU  - Klener P
LA  - cze
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Postizeni ledvin na podklade nemoci z ukladani lehkych retezcu.
PL  - Czech Republic
TA  - Sb Lek
JT  - Sbornik lekarsky
JID - 0025770
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Basement Membrane/metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Kidney Diseases/*diagnosis/immunology
MH  - Kidney Glomerulus/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Paraproteinemias/*diagnosis
EDAT- 2003/04/12 05:00
MHDA- 2003/04/25 05:00
CRDT- 2003/04/12 05:00
PHST- 2003/04/12 05:00 [pubmed]
PHST- 2003/04/25 05:00 [medline]
PHST- 2003/04/12 05:00 [entrez]
PST - ppublish
SO  - Sb Lek. 2002;103(3):397-403.