PMID- 12688625
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20191107
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 13
IP  - s15
DP  - 2002
TI  - Study on the prevention of allergy in Children in Europe (SPACE): allergic 
      sensitization in children at 1 year of age in a controlled trial of allergen 
      avoidance from birth.
PG  - 47-54
AB  - Several studies have demonstrated that early intervention may modulate the 
      natural course of atopic disease. Our objective was to prevent sensitization to 
      house-dust mite and food allergens, as well as the development of atopic symptoms 
      during infancy, by the combination of an educational package and the use of mite 
      allergen-impermeable mattress encasings. A multicentre European, 
      population-based, randomized, controlled study of children at increased atopic 
      risk [Study on the Prevention of Allergy in Children in Europe (SPACE)] was 
      performed in five countries (Austria, Germany, Greece, the UK, and Lithuania), 
      and included three cohorts - schoolchildren, toddlers, and newborns. We report on 
      the newborn cohort. A total of 696 newborns were included from Austria, the UK, 
      and Germany. Inclusion criteria were: a positive history of parental allergy; and 
      a positive skin-prick test or specific immunoglobulin E (IgE) (IgE > or = 1.43 
      kU/L) against at least one out of a panel of common aeroallergens in one or both 
      parents. At 1 year of age, the overall sensitization rate against the tested 
      allergens [dust-mite allergens: Dermatophagoides pteronyssinus and 
      Dermatophagoides farinae (Der p and Der f)] and food allergens (egg, milk) in the 
      prophylactic group was 6.21% vs. 10.67% in the control group. The prevalence of 
      sensitization against Der p was 1.86% in the prophylactic group vs. 5% in the 
      control group. In conclusion, we were able to demonstrate, in a group of newborns 
      at risk for atopic diseases, that the sensitization rate to a panel of aero- and 
      food allergens could be effectively decreased through the use of impermeable 
      mattress encasings and the implementation of easy-to-perform preventive measures.
FAU - Halmerbauer, Gerhard
AU  - Halmerbauer G
AD  - University Children's Hospital, Vienna, Austria.
FAU - Gartner, Christian
AU  - Gartner C
FAU - Schier, Michael
AU  - Schier M
FAU - Arshad, Hassan
AU  - Arshad H
FAU - Dean, Tara
AU  - Dean T
FAU - Koller, Dieter Y
AU  - Koller DY
FAU - Karmaus, Wilfried
AU  - Karmaus W
FAU - Kuehr, Joachim
AU  - Kuehr J
FAU - Forster, Johannes
AU  - Forster J
FAU - Urbanek, Radvan
AU  - Urbanek R
FAU - Frischer, Thomas
AU  - Frischer T
CN  - SPACE collaborative study team
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/adverse effects/immunology
MH  - Antibody Specificity/immunology
MH  - Antigens, Dermatophagoides/adverse effects/immunology
MH  - Europe/epidemiology
MH  - Floors and Floorcoverings
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity, Immediate/epidemiology/immunology/*prevention & control
MH  - Immunization
MH  - Immunoglobulin E/blood/immunology
MH  - Incidence
MH  - Infant Welfare
MH  - Infant, Newborn
MH  - Prospective Studies
MH  - Risk Reduction Behavior
MH  - Surveys and Questionnaires
EDAT- 2003/04/12 05:00
MHDA- 2003/05/16 05:00
CRDT- 2003/04/12 05:00
PHST- 2003/04/12 05:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2003/04/12 05:00 [entrez]
AID - 10.1034/j.1399-3038.13.s.15.11.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2002;13(s15):47-54. doi: 
      10.1034/j.1399-3038.13.s.15.11.x.