PMID- 12689373
OWN - NLM
STAT- MEDLINE
DCOM- 20030501
LR  - 20220311
IS  - 0962-8436 (Print)
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 358
IP  - 1431
DP  - 2003 Mar 29
TI  - Development and neurophysiology of mentalizing.
PG  - 459-73
AB  - The mentalizing (theory of mind) system of the brain is probably in operation 
      from ca. 18 months of age, allowing implicit attribution of intentions and other 
      mental states. Between the ages of 4 and 6 years explicit mentalizing becomes 
      possible, and from this age children are able to explain the misleading reasons 
      that have given rise to a false belief. Neuroimaging studies of mentalizing have 
      so far only been carried out in adults. They reveal a system with three 
      components consistently activated during both implicit and explicit mentalizing 
      tasks: medial prefrontal cortex (MPFC), temporal poles and posterior superior 
      temporal sulcus (STS). The functions of these components can be elucidated, to 
      some extent, from their role in other tasks used in neuroimaging studies. Thus, 
      the MPFC region is probably the basis of the decoupling mechanism that 
      distinguishes mental state representations from physical state representations; 
      the STS region is probably the basis of the detection of agency, and the temporal 
      poles might be involved in access to social knowledge in the form of scripts. The 
      activation of these components in concert appears to be critical to mentalizing.
FAU - Frith, Uta
AU  - Frith U
AD  - Institute of Cognitive Neuroscience, University College London, Queen Square, UK.
FAU - Frith, Christopher D
AU  - Frith CD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
SB  - IM
MH  - Child, Preschool
MH  - Cognition/*physiology
MH  - Gyrus Cinguli/anatomy & histology/*physiology
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - Prefrontal Cortex/anatomy & histology/*physiology
MH  - Temporal Lobe/anatomy & histology/*physiology
PMC - PMC1693139
EDAT- 2003/04/12 05:00
MHDA- 2003/05/02 05:00
PMCR- 2005/03/29
CRDT- 2003/04/12 05:00
PHST- 2003/04/12 05:00 [pubmed]
PHST- 2003/05/02 05:00 [medline]
PHST- 2003/04/12 05:00 [entrez]
PHST- 2005/03/29 00:00 [pmc-release]
AID - 10.1098/rstb.2002.1218 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2003 Mar 29;358(1431):459-73. doi: 
      10.1098/rstb.2002.1218.