PMID- 12691704
OWN - NLM
STAT- MEDLINE
DCOM- 20031205
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 5
DP  - 2003 May
TI  - Association between human papillomavirus 16 E6 variants and human leukocyte 
      antigen class I polymorphism in cervical cancer of Swedish women.
PG  - 538-42
AB  - Persistent infection with human papillomavirus (HPV), particularly HPV16, 
      represents the prime risk factor in cervical carcinogenesis. HPV variants (e.g., 
      within the E6 gene) together with immunogenetic factors of the host may be 
      responsible either for effective viral clearance, or alternatively, for viral 
      persistence. Peripheral blood from 27 HPV16 positive Swedish women with cervical 
      carcinoma, who had previously been tested for HPV16 E6 variants, was used for 
      human leukocyte antigen (HLA) class I typing. Women with HLA-B*44, HLA-B*51, or 
      HLA-B*57 who were infected with the HPV16 E6 variant L83V had an approximately 
      four- to fivefold increased risk for cancer compared with controls (odds ratio 
      [OR] = 3.5, 95% CI = 1.1-11.1, OR = 4.2, 95% CI = 1.19-14.69, or OR = 4.67, 95% 
      CI = 1.2-18.6, respectively). Epitope predictive algorithm with SYFPEITHI 
      revealed that the variant at amino acid 83 affects the binding affinity in 
      association with HLA-B*44. Interestingly, the HLA-B*15 allele seems protective 
      because it was absent in HPV16 positive cancer. It is concluded that specific HLA 
      class I alleles, combined with certain HPV16 E6 variants, may be crucial for 
      immune surveillance in cervical carcinogenesis. The evaluation of associations of 
      HLA alleles with HPV variants may be helpful in defining prognostic markers and 
      in designing vaccines capable of mediating immune protection against HPV 
      infection.
FAU - Zehbe, Ingeborg
AU  - Zehbe I
AD  - Department of Medical Microbiology (I.Z.), University of Mainz, Mainz, Germany. 
      zehbe@mail.uni-mainz.de
FAU - Mytilineos, Joannis
AU  - Mytilineos J
FAU - Wikstrom, Ingrid
AU  - Wikstrom I
FAU - Henriksen, Rudi
AU  - Henriksen R
FAU - Edler, Lutz
AU  - Edler L
FAU - Tommasino, Massimo
AU  - Tommasino M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (E6 protein, Human papillomavirus type 16)
RN  - 0 (HLA Antigens)
RN  - 0 (Oncogene Proteins, Viral)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Algorithms
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Oncogene Proteins, Viral/*genetics
MH  - Papillomaviridae/*genetics/immunology
MH  - Papillomavirus Infections/*genetics/immunology
MH  - *Repressor Proteins
MH  - Risk Factors
MH  - Sweden
MH  - Tumor Virus Infections/*genetics/immunology
MH  - Uterine Cervical Neoplasms/genetics/immunology/*virology
EDAT- 2003/04/15 05:00
MHDA- 2003/12/06 05:00
CRDT- 2003/04/15 05:00
PHST- 2003/04/15 05:00 [pubmed]
PHST- 2003/12/06 05:00 [medline]
PHST- 2003/04/15 05:00 [entrez]
AID - S0198885903000338 [pii]
AID - 10.1016/s0198-8859(03)00033-8 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 May;64(5):538-42. doi: 10.1016/s0198-8859(03)00033-8.