PMID- 12691707
OWN - NLM
STAT- MEDLINE
DCOM- 20031205
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 5
DP  - 2003 May
TI  - HLA A*02 allele frequencies and B haplotype associations in Western Indians.
PG  - 562-6
AB  - The population of Western India is described as Australoid or Proto-Australoid 
      elements with admixture from Caucasian, Mongoloid, and Aryan races. We 
      investigated the frequencies of human leukocyte antigen (HLA) A*02 alleles and 
      their B* allele haplotype associations among 664 healthy unrelated Western 
      Indians. Fifty-one of 204 serologically typed A2 individuals were analyzed for 56 
      molecular A*02 subtypes using high resolution polymerase chain reaction-reverse 
      line strip-sequence-specific oligonucleotide hybridization (PCR-RLS-SSOP). A 
      total of seven different A*02 alleles were identified, A*02011 (16%), A*0203 
      (16%), A*0205 (2%), A*0206 (2%), A*0211 (52.9%), A*0222 (4%), and A*0236 (8%). 
      The most common HLA B allele associated with A*02 was B*40. Among the 42 subtypes 
      HLA B*4006 (37.22%) was the most frequent subtype. HLA A*0211 was highly frequent 
      in this population, A*0206 and A*0203 are common alleles observed among Asian 
      populations, whereas A*0205 occurs in Caucasians and Africans and A*0222 has been 
      observed among Hispanics. A*0236 has been observed among the western Indians 
      exclusively. Most of the HLA A*02 subtypes observed were associated with B*4006 
      haplotype, although A*0236 was with B*0702 or B*1302 among the western Indians. 
      The prevalence of A*0211 at high frequencies, A*0222, A*0236 novel alleles along 
      with A*02 related haplotypes, demonstrate a substantial heterogeneity, which may 
      be a consequence of founder effect, racial admixture, or selection pressure due 
      to environmental factors.
FAU - Shankarkumar, Umapathy
AU  - Shankarkumar U
AD  - HLA Department, Institute of Immunohaematology (ICMR), K.E.M.Hospital, Parel, 
      Mumbai, India. shankarkumar16@hotmail.com
FAU - Prasanavar, Devaraj
AU  - Prasanavar D
FAU - Ghosh, Kanjaksha
AU  - Ghosh K
FAU - Mohanty, Dipika
AU  - Mohanty D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Ethnicity/genetics
MH  - Gene Frequency/*genetics
MH  - Genetic Heterogeneity
MH  - Genetic Variation
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - India
MH  - Polymerase Chain Reaction
EDAT- 2003/04/15 05:00
MHDA- 2003/12/06 05:00
CRDT- 2003/04/15 05:00
PHST- 2003/04/15 05:00 [pubmed]
PHST- 2003/12/06 05:00 [medline]
PHST- 2003/04/15 05:00 [entrez]
AID - S0198885903000326 [pii]
AID - 10.1016/s0198-8859(03)00032-6 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 May;64(5):562-6. doi: 10.1016/s0198-8859(03)00032-6.