PMID- 12692250
OWN - NLM
STAT- MEDLINE
DCOM- 20030527
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 77
IP  - 9
DP  - 2003 May
TI  - Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation 
      of extracellular regulated kinase pathway.
PG  - 5493-8
AB  - Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some 
      studies have demonstrated that IL-1 production was impaired in patients with 
      chronic infections of hepatitis C virus (HCV), implying that IL-1 may play a role 
      in viral clearance. Using an HCV subgenomic replicon cell line, we demonstrate 
      that IL-1 can effectively inhibit HCV subgenomic RNA replication and viral 
      protein expression, suggesting that IL-1 has direct antiviral activity. The 
      inhibitory effect is associated with the extracellular regulatory kinase (ERK) 
      activation. In addition, we also show that IL-1 can induce one of the 
      interferon-stimulated genes (ISGs), 1-8U, which exhibits antiviral activity. 
      However, it has no effect on the other ISG, 6-16, suggesting that IL-1 induces 
      novel antiviral pathways within a cell.
FAU - Zhu, Haizhen
AU  - Zhu H
AD  - Department of Pathology, Immunology, and Laboratory Medicine, University of 
      Florida College of Medicine, Gainesville 32610-0275, USA.
FAU - Liu, Chen
AU  - Liu C
LA  - eng
GR  - K08 DK002958/DK/NIDDK NIH HHS/United States
GR  - K08 DK02958/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Viral)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Enzyme Activation
MH  - Gene Expression Regulation
MH  - Hepacivirus/*drug effects/physiology
MH  - Humans
MH  - Interleukin-1/*pharmacology
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - RNA, Viral/*biosynthesis/drug effects/genetics
MH  - Replicon
MH  - Tumor Cells, Cultured
MH  - Virus Replication/*drug effects
PMC - PMC153991
EDAT- 2003/04/15 05:00
MHDA- 2003/05/28 05:00
PMCR- 2003/05/01
CRDT- 2003/04/15 05:00
PHST- 2003/04/15 05:00 [pubmed]
PHST- 2003/05/28 05:00 [medline]
PHST- 2003/04/15 05:00 [entrez]
PHST- 2003/05/01 00:00 [pmc-release]
AID - 2533 [pii]
AID - 10.1128/jvi.77.9.5493-5498.2003 [doi]
PST - ppublish
SO  - J Virol. 2003 May;77(9):5493-8. doi: 10.1128/jvi.77.9.5493-5498.2003.