PMID- 12694227
OWN - NLM
STAT- MEDLINE
DCOM- 20031112
LR  - 20190816
IS  - 0009-9163 (Print)
IS  - 0009-9163 (Linking)
VI  - 63
IP  - 3
DP  - 2003 Mar
TI  - The allelic loss of chromosome 3p25 with c-myc gain is related to the development 
      of clear-cell renal cell carcinoma.
PG  - 184-91
AB  - To explore the role of allelic losses at 3p25 and genetic alterations of 
      chromosome 8, we investigated the relationships between genetic alterations in 
      these chromosomal regions and clinicopathologic findings (such as tumor size and 
      grade), by employing fluorescence in situ hybridization (FISH). Fifty Japanese 
      clear-cell renal cell carcinomas (RCCs) were examined by dual-color FISH using 
      cosmid DNA probes for 3p25.1-25.3 combined with probes for chromosome 3 
      centromere, 8p12, 8p21.1, 8p21.3, 8p22 and 8q24.12-24.13 (c-myc), and chromosome 
      8 centromere. Deletion at 3p25.1-25.3 was detected in 38 patients (76%), while 
      8p12 deletion, 8p21.1 deletion, 8p21.3 deletion, 8p22 deletion and c-myc gain 
      were detected in 23 (46%), 25 (50%), 25 (50%), 25 (50%), and 20 patients (40%), 
      respectively. There was a significant correlation between 8p21.1 deletion, 8p21.3 
      deletion and 8p21.1 deletion with c-myc gain and tumor grade (p = 0.04, 0.04 and 
      0.02, respectively). Deletions at 8p21.1 and 8p21.3 with 3p deletion were 
      significantly related to tumor grade; the statistical significance was identical 
      to that of sole 8p deletion with tumor grade. The deletion at 3p25.1-25.3 with 
      c-myc gain showed a significant correlation with tumor size, indicating an 
      association with tumor progression. Our results suggest that the allelic loss of 
      chromosome 3p25 with c-myc gain is related to the development of clear-cell RCC.
CI  - Copyright Blackwell Munksgaard, 2003
FAU - Yamaguchi, S
AU  - Yamaguchi S
AD  - Department of Urology, Yamaguchi University School of Medicine, 1-1-1 
      Minami-Kogushi, Ube, Japan.
FAU - Yoshihiro, S
AU  - Yoshihiro S
FAU - Matsuyama, H
AU  - Matsuyama H
FAU - Nagao, K
AU  - Nagao K
FAU - Fukunaga, K
AU  - Fukunaga K
FAU - Matsumoto, H
AU  - Matsumoto H
FAU - Matsuda, K
AU  - Matsuda K
FAU - Oba, K
AU  - Oba K
FAU - Naito, K
AU  - Naito K
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Carcinoma, Renal Cell/*genetics/pathology
MH  - Cell Size
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Cosmids
MH  - Female
MH  - Genes, myc/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Kidney Neoplasms/*genetics/pathology
MH  - Loss of Heterozygosity/*genetics
MH  - Male
EDAT- 2003/04/16 05:00
MHDA- 2003/11/13 05:00
CRDT- 2003/04/16 05:00
PHST- 2003/04/16 05:00 [pubmed]
PHST- 2003/11/13 05:00 [medline]
PHST- 2003/04/16 05:00 [entrez]
AID - 035 [pii]
AID - 10.1034/j.1399-0004.2003.00035.x [doi]
PST - ppublish
SO  - Clin Genet. 2003 Mar;63(3):184-91. doi: 10.1034/j.1399-0004.2003.00035.x.