PMID- 12694583
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 61
IP  - 2
DP  - 2003 Feb
TI  - The association of HLA -A, -B, and -DRB1 genotypes with Graves' disease in 
      Taiwanese people.
PG  - 154-8
AB  - Graves' disease has been associated with different human leukocyte antigen (HLA) 
      genes in different races. To evaluate the association of HLA type in Taiwanese 
      with Graves' disease, the HLA-A, -B, and -DRB1 alleles in a total of 236 
      Taiwanese adults with Graves' disease and 533 racially matched normal control 
      subjects were examined using the PCR-SSOP (sequence specific oligonucleotide 
      probe) technique. The prevalence of HLA-A*0207, -B*2704, -B*4601, and -DRB1*0901 
      among patients with Graves' disease was found to be increased, with odds ratios 
      (OR) of 2.21, 3.82, 1.76 and 1.62, respectively. However, after correction for 
      multiple comparisons, the relative risk of HLA-A*0207 susceptibility to Graves' 
      disease remained statistically significant and the haplotype HLA-A*3303 -B*5801 
      -DRB1*0301 had a significantly protective effect. None of the other 2- or 3-locus 
      haplotypes showed any significantly increased risk. Although HLA-DRB1*1405 showed 
      an increased relative risk in patients with GO (Graves' opthalmopathy) (OR 4.61) 
      when compared with patients without GO, the relative risk after adjusting for the 
      number of comparisons was not significant. Taiwanese patients with Graves' 
      disease have HLA-associated susceptibility genes which are similar to those found 
      in Chinese patients in Hong Kong and Singapore. However, the finding in this 
      study of a higher frequency of HLA-A*0207 in Taiwanese with Graves' disease has 
      not been documented in any other ethnic group.
FAU - Huang, S-M
AU  - Huang SM
AD  - Department of Endocrine Surgery, Buddhist Tzu Chi University and Hospital, 
      Hualien, Taiwan. smhuang@mail.tcu.edu.tw
FAU - Wu, T-J
AU  - Wu TJ
FAU - Lee, T D
AU  - Lee TD
FAU - Yang, E K L
AU  - Yang EK
FAU - Shaw, C-K
AU  - Shaw CK
FAU - Yeh, C-C
AU  - Yeh CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Graves Disease/*genetics/*immunology
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Taiwan
EDAT- 2003/04/16 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/04/16 05:00
PHST- 2003/04/16 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/04/16 05:00 [entrez]
AID - 016 [pii]
AID - 10.1034/j.1399-0039.2003.00016.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2003 Feb;61(2):154-8. doi: 10.1034/j.1399-0039.2003.00016.x.