PMID- 12694741
OWN - NLM
STAT- MEDLINE
DCOM- 20030618
LR  - 20191210
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 536
IP  - 1-2
DP  - 2003 Apr 20
TI  - Multi-endpoint biological monitoring of phosphine workers.
PG  - 7-14
AB  - The pesticide phosphine (PH(3)) is a suspected carcinogen and a known clastogen 
      which has been shown to produce chromosome damage in agricultural workers. To 
      confirm and extend these results we evaluated 22 phosphine appliers and 26 
      controls matched for age and smoking status. Two independent methods were used to 
      evaluate exposure: fluorescence in situ hybridization (FISH) with 
      whole-chromosome paints of chromosomes 1, 2, and 4 labeled in a single color to 
      quantify translocations in peripheral lymphocytes, and the glycophorin A (GPA) 
      assay to quantify phenotypically mutant (NO or NN) erythrocytes. No differences 
      in the frequency of translocations were found in the phosphine appliers compared 
      to the controls, and no effect of cigarette smoking was observed. However, a 
      significant increase in the frequency of translocations with age (P<0.0001) was 
      seen. No effect of phosphine exposure or cigarette smoking was observed in the 
      GPA assay. These results are in contrast to previous findings from this same 
      population which showed an increase in chromosome aberrations among phosphine 
      appliers. The results are most easily interpreted as supporting the effectiveness 
      of the personal protective equipment that is now worn by the workers but which 
      was not employed prior to and during the earlier studies.
FAU - Tucker, James D
AU  - Tucker JD
AD  - Biology and Biotechnology Research Program, P.O. Box 808, L-448 Lawrence 
      Livermore National Laboratory, Livermore, CA 94551, USA. 
      jtucker@biology.biosci.wayne.edu
FAU - Moore, Dan H 2nd
AU  - Moore DH 2nd
FAU - Ramsey, Marilyn J
AU  - Ramsey MJ
FAU - Kato, Paula
AU  - Kato P
FAU - Langlois, Richard G
AU  - Langlois RG
FAU - Burroughs, Barbara
AU  - Burroughs B
FAU - Long, Leslie
AU  - Long L
FAU - Garry, Vincent F
AU  - Garry VF
LA  - eng
GR  - R01 CA 61183/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Glycophorins)
RN  - 0 (Insecticides)
RN  - 0 (Phosphines)
RN  - FW6947296I (phosphine)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Environmental Monitoring/*methods
MH  - Erythrocytes/drug effects/metabolism
MH  - Glycophorins/drug effects/metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Insecticides/*adverse effects
MH  - Lymphocytes/drug effects
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure
MH  - Phosphines/*adverse effects
MH  - Reference Values
MH  - Regression Analysis
MH  - Smoking
MH  - *Translocation, Genetic
EDAT- 2003/04/16 05:00
MHDA- 2003/06/19 05:00
CRDT- 2003/04/16 05:00
PHST- 2003/04/16 05:00 [pubmed]
PHST- 2003/06/19 05:00 [medline]
PHST- 2003/04/16 05:00 [entrez]
AID - S1383571803000147 [pii]
AID - 10.1016/s1383-5718(03)00014-7 [doi]
PST - ppublish
SO  - Mutat Res. 2003 Apr 20;536(1-2):7-14. doi: 10.1016/s1383-5718(03)00014-7.