PMID- 12699667
OWN - NLM
STAT- MEDLINE
DCOM- 20040130
LR  - 20190815
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 24
IP  - 13
DP  - 2003 Jun
TI  - Successful application of tissue engineered vascular autografts: clinical 
      experience.
PG  - 2303-8
AB  - Foreign materials often used in cardiovascular surgery may cause unwanted side 
      effects and reduced growth potential. To resolve these problems, we have designed 
      a tissue-engineering technique that utilizes bone marrow cells (BMCs) in clinical 
      treatments. To obtain tissue-engineered material, we harvested saphenous vein 
      samples from patients, which were then minced, cultured and seeded onto a 
      biodegradable scaffold. The first operation was performed in May 1999 as 
      previously described (N. Engl. J. Med. 344 (7) (2001) 532) and this method was 
      repeated on two other patients. From November 2001, we used aspirated BMCs as the 
      cell source, which were seeded onto the scaffold on the day of surgery. This 
      method was applied in 22 patients. There was no morbidity such as thrombogenic 
      complications, stenosis or obstruction of tissue-engineered autografts, and no 
      mortality due to these techniques. These results indicate that BMCs seeded onto a 
      biodegradable scaffold to establish tissue-engineered vascular autografts (TEVAs) 
      is an ideal strategy, and present strong evidence for the justification and 
      validity of our protocol in clinical trials of tissue engineering.
FAU - Matsumura, Goki
AU  - Matsumura G
AD  - Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women's Medical 
      University, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan.
FAU - Hibino, Narutoshi
AU  - Hibino N
FAU - Ikada, Yoshito
AU  - Ikada Y
FAU - Kurosawa, Hiromi
AU  - Kurosawa H
FAU - Shin'oka, Toshiharu
AU  - Shin'oka T
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
SB  - IM
MH  - Adolescent
MH  - *Blood Vessel Prosthesis
MH  - Bone Marrow Transplantation/*methods
MH  - Cardiac Surgical Procedures/*methods
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Saphenous Vein/*transplantation
MH  - Tissue Engineering/*methods
MH  - Tissue Transplantation/*methods
MH  - Transplantation, Autologous
MH  - *Transplants
EDAT- 2003/04/18 05:00
MHDA- 2004/01/31 05:00
CRDT- 2003/04/18 05:00
PHST- 2003/04/18 05:00 [pubmed]
PHST- 2004/01/31 05:00 [medline]
PHST- 2003/04/18 05:00 [entrez]
AID - S0142961203000437 [pii]
AID - 10.1016/s0142-9612(03)00043-7 [doi]
PST - ppublish
SO  - Biomaterials. 2003 Jun;24(13):2303-8. doi: 10.1016/s0142-9612(03)00043-7.