PMID- 12699885
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 142
IP  - 2
DP  - 2003 Apr 15
TI  - Is monosomy 5 an uncommon aberration? Fluorescence in situ hybridization reveals 
      translocations and deletions in myelodysplastic syndromes or acute myelocytic 
      leukemia.
PG  - 107-14
AB  - Acquired loss of material from chromosome 5 in bone marrow cells is common in 
      myelodysplastic syndromes (MDS) and acute myelocytic leukemia (AML). In this 
      study, we have applied fluorescence in situ hybridization (FISH) analyses with 
      probes for the three regions 5p15.2, 5q31, 5q33-q34, and whole chromosome 5 
      painting probes (WCP 5) to investigate what further information could be gained 
      regarding the cytogenetic abnormalities of chromosome 5 in 35 patients with MDS 
      or AML. With FISH, a del(5q) was found in all patients except for two. 
      Translocations of material from chromosome 5 were found in 10 patients. Among 16 
      patients with clones of monosomy 5 seen by cytogenetics, 14 had deletions or 
      translocations. Different breakpoints on chromosome 5 were observed. In 
      conclusion, the extended FISH analyses yielded additional information about 
      chromosome 5 abnormalities in 60% of the patients. Of interest is the finding of 
      a high proportion of translocations and that monosomy 5 occurs less often than is 
      generally believed.
FAU - Bram, Susanne
AU  - Bram S
AD  - Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University 
      Hospital, Goteborg, Sweden.
FAU - Swolin, Birgitta
AU  - Swolin B
FAU - Rodjer, Stig
AU  - Rodjer S
FAU - Stockelberg, Dick
AU  - Stockelberg D
FAU - Ogard, Inger
AU  - Ogard I
FAU - Back, Hans
AU  - Back H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Monosomy/*genetics
MH  - Myelodysplastic Syndromes/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2003/04/18 05:00
MHDA- 2003/05/16 05:00
CRDT- 2003/04/18 05:00
PHST- 2003/04/18 05:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2003/04/18 05:00 [entrez]
AID - S0165460802008361 [pii]
AID - 10.1016/s0165-4608(02)00836-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Apr 15;142(2):107-14. doi: 
      10.1016/s0165-4608(02)00836-1.