PMID- 12699891
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 142
IP  - 2
DP  - 2003 Apr 15
TI  - Monosomy 21 in hematologic diseases.
PG  - 137-41
AB  - Monosomy 21 mosaicism as a sole cytogenetic abnormality is very uncommon, with 47 
      cases described in the literature. We identified five cases of low-level monosomy 
      21 mosaicism since 1998, none of which were confirmed by fluorescence in situ 
      hybridization (FISH) analysis or follow-up cytogenetic studies. These five cases, 
      and many of the previously reported cases, probably represent the random 
      appearance of several monosomy 21 cells as artifacts of cell culture or 
      microscope slide preparation. The most convincing reported cases of monosomy 21 
      mosaicism suggest a rare association of monosomy 21 with acute myelocytic 
      leukemia and chronic lymphocytic leukemia. Future cases suggestive of monosomy 21 
      mosaicism should be confirmed by analysis of additional metaphase cells and by 
      FISH analysis of interphase cells.
FAU - Van Dyke, Daniel L
AU  - Van Dyke DL
AD  - Department of Medical Genetics, Henry Ford Health System, 2799 West Grand 
      Boulevard, Clara Ford Pavillion, Detroit, MI 48202, USA.
FAU - Wiktor, Anne
AU  - Wiktor A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Female
MH  - Hematologic Diseases/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Monosomy/*genetics
MH  - Mosaicism/genetics
EDAT- 2003/04/18 05:00
MHDA- 2003/05/16 05:00
CRDT- 2003/04/18 05:00
PHST- 2003/04/18 05:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2003/04/18 05:00 [entrez]
AID - S0165460802007963 [pii]
AID - 10.1016/s0165-4608(02)00796-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Apr 15;142(2):137-41. doi: 
      10.1016/s0165-4608(02)00796-3.