PMID- 12700203
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20071115
IS  - 0006-3363 (Print)
IS  - 0006-3363 (Linking)
VI  - 69
IP  - 2
DP  - 2003 Aug
TI  - Effects of sex chromosome dosage on placental size in mice.
PG  - 483-8
AB  - Mice of the XO genotype with a paternally derived X chromosome (XpO) have 
      placental hyperplasia in late pregnancy, although in early pregnancy the 
      ectoplacental cone, a placental precursor, is smaller in XpO mice than in their 
      XX sibs. This early size deficiency of the ectoplacental cone is apparently a 
      consequence of Xp imprinting, because XmO embryos (with a maternally derived X 
      chromosome) are unaffected. In the present study we sought to establish whether 
      XpO placental hyperplasia in late pregnancy is also a consequence of Xp 
      imprinting. Placental weight data were first collected from litters that included 
      XpO or XmO fetuses and XX controls. Comparison of XO placentae with XX placentae 
      showed that XpO and XmO placentae are hyperplastic. This finding suggested that 
      the hyperplasia might be an X dosage effect, and this hypothesis was supported by 
      the finding that XY male fetuses from the same crosses also had larger placentae 
      than their XX sibs. Further analysis of a range of sex-chromosome variant 
      genotypes, including XmYSry-negative females and XXSry transgenic males, showed 
      that mouse fetuses with one X chromosome consistently had larger placentae than 
      littermates with two X chromosomes, independent of their gonadal/androgen status.
FAU - Ishikawa, Hitoshi
AU  - Ishikawa H
AD  - National Institute for Medical Research, London NW7 1AA, United Kingdom.
FAU - Rattigan, Aine
AU  - Rattigan A
FAU - Fundele, Reinald
AU  - Fundele R
FAU - Burgoyne, Paul S
AU  - Burgoyne PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030416
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - Embryo, Mammalian/physiology
MH  - Embryonic and Fetal Development/physiology
MH  - Female
MH  - *Gene Dosage
MH  - Genotype
MH  - Male
MH  - Mice
MH  - Organ Size/physiology
MH  - Placenta/*anatomy & histology
MH  - Pregnancy
MH  - Sex Chromosomes/*genetics
MH  - X Chromosome/genetics
MH  - Y Chromosome/genetics
EDAT- 2003/04/18 05:00
MHDA- 2004/04/07 05:00
CRDT- 2003/04/18 05:00
PHST- 2003/04/18 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2003/04/18 05:00 [entrez]
AID - biolreprod.102.012641 [pii]
AID - 10.1095/biolreprod.102.012641 [doi]
PST - ppublish
SO  - Biol Reprod. 2003 Aug;69(2):483-8. doi: 10.1095/biolreprod.102.012641. Epub 2003 
      Apr 16.