PMID- 12701184
OWN - NLM
STAT- MEDLINE
DCOM- 20030610
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 61
IP  - 3
DP  - 2003 Mar
TI  - [Contribution of neurotrophic factors and cytokines to schizophrenia].
PG  - 521-8
AB  - Abnormal development of the brain is implicated in the etiology and/or pathology 
      of various psychiatric diseases, including schizophrenia. Current evidence 
      indicates that neurotrophic factors can strongly influence neuronal phenotypic 
      differentiation and subsequent neuronal function in synaptic plasticity. Among 
      various neurotrophic factors, the expression of brain-derived neurotrophic 
      factor(BDNF) and epidermal growth factor (EGF) is impaired in the brain as well 
      as in the periphery of patients with schizophrenia. Based on this result, a novel 
      animal model for schizophrenia has been established by perturbing the 
      neurotrophic signaling during development. This review summarizes the latest 
      progress of these studies.
FAU - Nawa, Hiroyuki
AU  - Nawa H
AD  - Brain Research Institute, Niigata University.
FAU - Futamura, Takashi
AU  - Futamura T
FAU - Mizuno, Makoto
AU  - Mizuno M
FAU - Takahashi, Makoto
AU  - Takahashi M
FAU - Toyooka, Kazuhiko
AU  - Toyooka K
FAU - Someya, Toshiyuki
AU  - Someya T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Nerve Growth Factors)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/growth & development
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - Cell Differentiation
MH  - Cytokines/*physiology
MH  - Disease Models, Animal
MH  - Epidermal Growth Factor/physiology
MH  - Humans
MH  - Nerve Growth Factors/*physiology
MH  - Neuronal Plasticity
MH  - Neurons/cytology/physiology
MH  - Schizophrenia/*etiology
MH  - Synapses/physiology
RF  - 12
EDAT- 2003/04/19 05:00
MHDA- 2003/06/11 05:00
CRDT- 2003/04/19 05:00
PHST- 2003/04/19 05:00 [pubmed]
PHST- 2003/06/11 05:00 [medline]
PHST- 2003/04/19 05:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2003 Mar;61(3):521-8.