PMID- 12702001
OWN - NLM
STAT- MEDLINE
DCOM- 20031002
LR  - 20221207
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 15
IP  - 6 Suppl
DP  - 2002 Dec
TI  - Postprandial dysmetabolism and large-vessel disease.
PG  - 3-8
AB  - The increased cardiovascular disease morbidity and mortality in people with Type 
      2 diabetes mellitus (T2DM) is not explained by the prevalence of cardiovascular 
      disease risk factors and is often attributed to poor glycaemic control. 
      Epidemiological studies have shown fasting and especially postprandial or 
      post-challenge hyperglycaemia to be strong predictors of cardiovascular disease 
      morbidity and mortality in people with either T2DM or prediabetic states. 
      Post-challenge hyperglycaemia in people with impaired glucose tolerance has been 
      associated with increased cardiovascular disease mortality, regardless of the 
      fasting blood glucose (FBG) concentration, but the relationship between FBG and 
      cardiovascular disease was dependent on post-challenge glycaemia. Improving blood 
      glucose and HbA1c concentrations by intensive insulin treatment reduced the risk 
      of cardiovascular disease in a small group of Japanese patients with T2DM and, in 
      another study, improved the outcome in patients with T2DM who had suffered a 
      myocardial infarction. However, on the basis of currently available data, there 
      is no evidence that improved glycaemic control results in a significant reduction 
      of cardiovascular disease risk in people with T2DM. The aim in the present 
      article is to review existing information on the relationship between glycaemia, 
      particularly postprandial glucose concentrations, and cardiovascular disease in 
      people with T2DM or impaired glucose tolerance, and to point at possible 
      mechanisms by which postprandial hyperglycaemia could lead to cardiovascular 
      disease.
FAU - Segal, P
AU  - Segal P
AD  - Diabetes Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel. 
      psegal@post.tau.ac.il
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/etiology/metabolism/*mortality
MH  - Diabetes Mellitus, Type 2/complications/drug therapy/*metabolism
MH  - Fasting
MH  - Glycated Hemoglobin/analysis
MH  - Hyperglycemia/metabolism/*physiopathology
MH  - Hypoglycemic Agents/therapeutic use
MH  - Postprandial Period
MH  - Risk Factors
RF  - 41
EDAT- 2003/04/19 05:00
MHDA- 2003/10/03 05:00
CRDT- 2003/04/19 05:00
PHST- 2003/04/19 05:00 [pubmed]
PHST- 2003/10/03 05:00 [medline]
PHST- 2003/04/19 05:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2002 Dec;15(6 Suppl):3-8.